Do Event-Related Evoked Potentials Reflect Apathy Tendency and Motivation?
Do Event-Related Evoked Potentials Reflect Apathy Tendency and Motivation?
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DOI：
10.3389/fnhum.2018.00011
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发表时间：
2018
影响因子：
2.9
通讯作者：
Yamaguchi S
中科院分区：
文献类型：
--
作者：
Takayoshi H;Onoda K;Yamaguchi S
冷漠是一种动机减弱的精神状态。虽然奖励系统作为人类大脑中动机的基础已经用神经成像技术进行了广泛的研究，但动机和冷漠的电生理相关性还没有得到充分的研究。因此，在14名健康志愿者中，我们研究了事件相关诱发电位（ERP）是否在一个简单的数字辨别任务中获得的奖励/无奖励反映冷漠倾向和奖励依赖的倾向，这是分别使用冷漠量表和气质和性格量表（TCI）进行评估。参与者被要求判断一个数字的大小，并根据他们在每次试验中的表现获得反馈。与反馈刺激相关的P3波幅仅在奖励条件下增加。此外，奖赏条件下负反馈刺激相关的P2波幅与TCI的奖赏依赖倾向呈正相关，而正反馈刺激相关的P3波幅与冷漠得分呈负相关。我们的研究结果表明，P2和P3 ERPs的奖励相关的反馈刺激调制的动机奖励依赖和冷漠的倾向，在一个独特的方式，因此，目前的范式可能是有用的研究与动机相关的大脑活动。
Apathy is a mental state of diminished motivation. Although the reward system as the foundation of the motivation in the human brain has been studied extensively with neuroimaging techniques, the electrophysiological correlates of motivation and apathy have not been fully explored. Thus, in 14 healthy volunteers, we examined whether event-related evoked potentials (ERP) obtained during a simple number discrimination task with/without rewards reflected apathy tendency and a reward-dependent tendency, which were assessed separately using the apathy scale and the temperament and character inventory (TCI). Participants were asked to judge the size of a number, and received feedback based on their performance in each trial. The P3 amplitudes related to the feedback stimuli increased only in the reward condition. Furthermore, the P2 amplitudes related to the negative feedback stimuli in the reward condition had a positive correlation with the reward-dependent tendency in TCI, whereas the P3 amplitudes related to the positive feedback stimuli had a negative correlation with the apathy score. Our result suggests that the P2 and P3 ERPs to reward-related feedback stimuli are modulated in a distinctive manner by the motivational reward dependence and apathy tendency, and thus the current paradigm may be useful for investigating the brain activity associated with motivation.
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DOI：
10.1016/0168-5597(84)90016-9
发表时间：
1984-01-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
KNIGHT, RT
通讯作者：
KNIGHT, RT
影响因子：
3.9
作者：
Martin-Soelch, Chantal
通讯作者：
Martin-Soelch, Chantal
影响因子：
56.9
作者：
Gehring, WJ;Willoughby, AR
通讯作者：
Willoughby, AR
影响因子：
2.6
作者：
Foti, Dan;Hajcak, Greg
通讯作者：
Hajcak, Greg
DOI：
10.1590/1414-431x20143622
发表时间：
2014-07
期刊：
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
影响因子：
--
作者：
Han HY;Gan T;Li P;Li ZJ;Guo M;Yao SM
通讯作者：
Yao SM