Haplotype diversity in mitochondrial DNA reveals the multiple origins of Tibetan horse.
Haplotype diversity in mitochondrial DNA reveals the multiple origins of Tibetan horse.
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线粒体DNA单倍型多样性揭示藏马的多重起源
DOI：
10.1371/journal.pone.0201564
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Zhang H
中科院分区：
文献类型：
--
作者：
Yang L;Kong X;Yang S;Dong X;Yang J;Gou X;Zhang H
藏马是青藏高原特有的物种，在该地区具有相当大的经济价值。然而，我们目前几乎没有遗传证据来证实该品种是否起源于西藏，或者它是否通过古老的迁徙路线进入该地区。在本研究中，我们分析了2050匹马的线粒体DNA(MtDNA)的高变量片段I序列，其中包括来自5个藏族群体的290匹马和来自亚洲其他地区的1760匹马。网络分析揭示了藏马的多个母系血统。亚谱系F3的成分分析表明，从东到西频率递减，从内蒙古向南和向北反映了这一趋势。群体遗传学分析表明，藏东地区的德钦马与中国北部的宁强马的亲缘关系比与其他藏马和云南马的亲缘关系更近。这些结果表明，藏马首先从中亚迁徙到蒙古，然后向南迁徙到西藏东部(德钦附近)，最后向西迁徙到西藏其他地区。我们还确定了一个新的谱系K，它主要由藏马和云南马组成，这表明一些藏马品种来自当地野马的本土驯化起源。综上所述，我们的研究表明，现代藏马品种起源于中国以外的地方野马和外来驯化群体的导入。
The Tibetan horse is a species endemic to the Tibetan plateau, with considerable economic value in the region. However, we currently have little genetic evidence to verify whether the breed originated in Tibet or if it entered the area via an ancient migratory route. In the present study, we analyzed the hypervariable segment I sequences of mitochondrial DNA (mtDNA) in 2,050 horses, including 290 individuals from five Tibetan populations and 1,760 from other areas across Asia. Network analysis revealed multiple maternal lineages in the Tibetan horse. Component analysis of sub-lineage F3 indicated that it decreased in frequency from east to west, a trend reflected both southward and northward from Inner Mongolia. Analysis of population genetics showed that the Deqen horse of eastern Tibet was more closely related to the Ningqiang horse of northern China than to other Tibetan horses or the Yunnan horse. These results indicated that the Tibetan horse migrated first from Central Asia to Mongolia, moved south to eastern Tibet (near Deqen), then finally westward to other regions of Tibet. We also identified a novel lineage K that mainly comprises Tibetan and Yunnan horses, suggesting autochthonous domesticated origin for some Tibetan horse breeds from local wild horses. In conclusion, our study demonstrated that modern Tibetan horse breeds originated from the introgression of local wild horses with exotic domesticated populations outside China.
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DOI：
10.1073/pnas.152330099
发表时间：
2002-08-06
影响因子：
11.1
作者：
Jansen, T;Forster, P;Olek, K
通讯作者：
Olek, K
影响因子：
2
作者：
Yang, Yunzhou;Zhu, Qiyun;Wu, Changxin
通讯作者：
Wu, Changxin
线粒体DNA多样性的起源。
影响因子：
3.4
作者：
Guo, Songchang;Savolainen, Peter;Su, Jianping;Zhang, Qian;Qi, Delin;Zhou, Jie;Zhong, Yang;Zhao, Xinquan;Liu, Jianquan
通讯作者：
Liu, Jianquan
影响因子：
3.7
作者：
Cieslak M;Pruvost M;Benecke N;Hofreiter M;Morales A;Reissmann M;Ludwig A
通讯作者：
Ludwig A
影响因子：
3.8
作者：
Ding, Z-L;Oskarsson, M.;Ardalan, A.;Angleby, H.;Dahlgren, L-G;Tepeli, C.;Kirkness, E.;Savolainen, P.;Zhang, Y-P
通讯作者：
Zhang, Y-P