Origins of domestic dog in southern East Asia is supported by analysis of Y-chromosome DNA.
Origins of domestic dog in southern East Asia is supported by analysis of Y-chromosome DNA.
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DOI：
10.1038/hdy.2011.114
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发表时间：
2012-05
期刊：
影响因子：
3.8
通讯作者：
Zhang, Y-P
中科院分区：
文献类型：
--
作者：
Ding, Z-L;Oskarsson, M.;Ardalan, A.;Angleby, H.;Dahlgren, L-G;Tepeli, C.;Kirkness, E.;Savolainen, P.;Zhang, Y-P
全球线粒体DNA （mtDNA）数据表明，狗起源于长江以南亚洲（ASY）的狼驯化，其他地方的狗-狼杂交遗传贡献较小。考古数据和常染色体单核苷酸多态性数据表明狗起源于欧洲和/或西南亚，但由于这些数据集缺乏ASY数据，指向ASY的证据可能被忽视了。因此，有必要对全球数据集（包括ASY）的其他标记进行分析，以测试mtDNA系统地理是否反映了狗的实际历史，而不仅仅是随机事件或选择。在这里，我们分析了全世界151只狗的14 437 bp的y染色体DNA序列。我们发现28个单倍型分布在5个单倍群中。两个单倍群是普遍共有的，其中包括46%的狗携带的三个单倍型，但另外两个单倍群主要局限于东亚。在ASY中发现了最高的遗传多样性和几乎完全的系统发育覆盖。据估计，这151只狗来自13-24只狼的祖先，但没有迹象表明驯化后狗与狼杂交。因此，y染色体和mtDNA数据给出了狗的系统地理学惊人相似的图片，最重要的是，大约50%的基因库是普遍共享的，但只有ASY拥有几乎全部的遗传多样性，这样所有其他地区的基因库可能都来自ASY。这证实了ASY是狼驯化的主要地区，也可能是唯一的地区，大量的狼被驯化，随后的狗与狼的杂交对狗的基因库贡献不大。
Global mitochondrial DNA (mtDNA) data indicates that the dog originates from domestication of wolf in Asia South of Yangtze River (ASY), with minor genetic contributions from dog–wolf hybridisation elsewhere. Archaeological data and autosomal single nucleotide polymorphism data have instead suggested that dogs originate from Europe and/or South West Asia but, because these datasets lack data from ASY, evidence pointing to ASY may have been overlooked. Analyses of additional markers for global datasets, including ASY, are therefore necessary to test if mtDNA phylogeography reflects the actual dog history and not merely stochastic events or selection. Here, we analyse 14 437 bp of Y-chromosome DNA sequence in 151 dogs sampled worldwide. We found 28 haplotypes distributed in five haplogroups. Two haplogroups were universally shared and included three haplotypes carried by 46% of all dogs, but two other haplogroups were primarily restricted to East Asia. Highest genetic diversity and virtually complete phylogenetic coverage was found within ASY. The 151 dogs were estimated to originate from 13–24 wolf founders, but there was no indication of post-domestication dog–wolf hybridisations. Thus, Y-chromosome and mtDNA data give strikingly similar pictures of dog phylogeography, most importantly that roughly 50% of the gene pools are shared universally but only ASY has nearly the full range of genetic diversity, such that the gene pools in all other regions may derive from ASY. This corroborates that ASY was the principal, and possibly sole region of wolf domestication, that a large number of wolves were domesticated, and that subsequent dog–wolf hybridisation contributed modestly to the dog gene pool.
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影响因子：
10.7
作者：
Pang JF;Kluetsch C;Zou XJ;Zhang AB;Luo LY;Angleby H;Ardalan A;Ekström C;Sköllermo A;Lundeberg J;Matsumura S;Leitner T;Zhang YP;Savolainen P
通讯作者：
Savolainen P
影响因子：
56.9
作者：
Kirkness, EF;Bafna, V;Venter, JC
通讯作者：
Venter, JC
DOI：
10.1016/j.cub.2009.07.032
发表时间：
2009-09-15
期刊：
Current biology : CB
影响因子：
--
作者：
Xue Y;Wang Q;Long Q;Ng BL;Swerdlow H;Burton J;Skuce C;Taylor R;Abdellah Z;Zhao Y;Asan;MacArthur DG;Quail MA;Carter NP;Yang H;Tyler-Smith C
通讯作者：
Tyler-Smith C
影响因子：
2.9
作者：
Natanaelsson C;Oskarsson MC;Angleby H;Lundeberg J;Kirkness E;Savolainen P
通讯作者：
Savolainen P
影响因子：
56.9
作者：
Savolainen, P;Zhang, YP;Leitner, T
通讯作者：
Leitner, T