Comprehensive Analysis of Enhancer RNAs Identifies LINC00689 and ELFN1-AS1 as Novel Prognostic Biomarkers in Uveal Melanoma.
Comprehensive Analysis of Enhancer RNAs Identifies LINC00689 and ELFN1-AS1 as Novel Prognostic Biomarkers in Uveal Melanoma.
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DOI：
10.1155/2022/5994800
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Gu H
中科院分区：
文献类型：
--
作者：
Zhao S;Jiang H;Liu J;Li DY;Li B;Long QR;Zheng L;Gu H
增强子RNA（eRNA）已经成为包括葡萄膜黑色素瘤在内的几种肿瘤的病理学中的关键参与者。本研究旨在探讨eRNAs在葡萄膜黑色素瘤（UVM）患者中的预后价值。UVM患者的表达数据和生存数据从TCGA和GSE 22138数据集下载。Kaplan-Meier法结合log-rank检验筛选UVM中与生存相关的eRNA。应用GEPIA分析eRNA表达与无病生存期之间的关系。应用KEGG分析来探索关键eRNA的潜在信号通路。通过R包生存率的多变量分析进一步探讨eRNA的预后价值。eRNA在泛癌症中得到验证。在这项研究中，我们根据TCGA数据集在UVM中鉴定了89个与生存相关的eRNA。基于GSE 22138数据集，我们在UVM中发现了27个与生存相关的eRNA。在两个数据集中，只有两个eRNA（LINC 00689和ELFN 1-AS 1）重叠。多因素分析结果显示LINC 00689和ELFN 1-AS 1均为UVM患者的独立预后因素。泛癌症验证结果进一步证实了LINC 00689和ELFN 1-AS 1在8种肿瘤中的预后价值。总之，我们鉴定了两种新的UVM相关eRNA，LINC 00689和ELFN 1-AS 1，它们可以作为UVM患者的预后和诊断生物标志物用于临床决策。
Enhancer RNAs (eRNAs) have emerged as key players in the pathology of several tumors, including uveal melanoma. Here, we aimed to explore the prognostic values of eRNAs in uveal melanoma (UVM) patients. The expressing data and survival data of UVM patients were downloaded from TCGA and GSE22138 datasets. The Kaplan-Meier methods with the log-rank test were applied to screen survival-related eRNAs in UVM. GEPIA was applied to analyze the associations between expressions of eRNA and disease-free survival. KEGG assays were applied to explore the potential signaling pathways of the key eRNA. The prognostic values of eRNAs were further explored by multivariate assays by the R package survival. The eRNAs were validated in pan-cancer. In this study, we identified 89 survival-related eRNAs in UVM based on TCGA datasets. Based on GSE22138 datasets, we found 27 survival-related eRNAs in UVM. Only two eRNAs (LINC00689 and ELFN1-AS1) were overlapped in both two datasets. The results of multivariate analysis revealed that both LINC00689 and ELFN1-AS1 were independent prognostic factors in UVM patients. The pan-cancer validation results further confirmed the prognostic values of LINC00689 and ELFN1-AS1 in eight tumors. Overall, we identified two novel UVM-related eRNAs, LINC00689 and ELFN1-AS1 which may serve as prognostic and diagnostic biomarkers of UVM patients for clinical decision-making.
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