GABAergic neuron specification in the spinal cord, the cerebellum, and the cochlear nucleus.
GABAergic neuron specification in the spinal cord, the cerebellum, and the cochlear nucleus.
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DOI：
10.1155/2012/921732
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发表时间：
2012
影响因子：
3.1
通讯作者：
Hoshino M
中科院分区：
文献类型：
--
作者：
Hori K;Hoshino M
在神经系统中，有各种各样的神经元细胞类型，它们在形态、生理和组织化学上都具有不同的特征。这些不同类型的神经元可分为两类：兴奋性神经元和抑制性神经元。这两种类型的活动的精心平衡对于引发更高的大脑功能非常重要，因为它的不平衡可能导致神经系统疾病，如癫痫和痛觉过敏。在中枢神经系统中，抑制性神经元主要以gaba能神经元为代表，也有甘氨酸能神经元等例外。虽然指定gaba能神经元的机制最初是在端脑中研究的，但关键分子的鉴定，如胰腺转录因子1a (Ptf1a)，以及最近开发的遗传谱系追踪方法，使我们更好地了解了其他大脑区域（如脊髓、小脑和耳蜗核）的gaba能特异性。
In the nervous system, there are a wide variety of neuronal cell types that have morphologically, physiologically, and histochemically different characteristics. These various types of neurons can be classified into two groups: excitatory and inhibitory neurons. The elaborate balance of the activities of the two types is very important to elicit higher brain function, because its imbalance may cause neurological disorders, such as epilepsy and hyperalgesia. In the central nervous system, inhibitory neurons are mainly represented by GABAergic ones with some exceptions such as glycinergic. Although the machinery to specify GABAergic neurons was first studied in the telencephalon, identification of key molecules, such as pancreatic transcription factor 1a (Ptf1a), as well as recently developed genetic lineage-tracing methods led to the better understanding of GABAergic specification in other brain regions, such as the spinal cord, the cerebellum, and the cochlear nucleus.
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影响因子：
2.5
作者：
BATINI, C;COMPOINT, C;GUEGAN, M
通讯作者：
GUEGAN, M
影响因子：
64.8
作者：
BenArie, N;Bellen, HJ;Zoghbi, HY
通讯作者：
Zoghbi, HY
影响因子：
4.6
作者：
Chizhikov, Victor V.;Lindgren, Anne G.;Millen, Kathleen J.
通讯作者：
Millen, Kathleen J.
DOI：
10.1242/dev.005868
发表时间：
2007-10
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Del Barrio MG;Taveira-Marques R;Muroyama Y;Yuk DI;Li S;Wines-Samuelson M;Shen J;Smith HK;Xiang M;Rowitch D;Richardson WD
通讯作者：
Richardson WD
影响因子：
25
作者：
Cheng, LP;Arata, A;Ma, QF
通讯作者：
Ma, QF