Altered GDF15 and FGF21 Levels in Response to Strenuous Exercise: A Study in Marathon Runners.
Altered GDF15 and FGF21 Levels in Response to Strenuous Exercise: A Study in Marathon Runners.
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响应剧烈运动而改变了GDF15和FGF21水平：对马拉松运动员的研究。
DOI：
10.3389/fphys.2020.550102
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发表时间：
2020
影响因子：
4
通讯作者：
Villarroya F
中科院分区：
文献类型：
--
作者：
Campderrós L;Sánchez-Infantes D;Villarroya J;Nescolarde L;Bayès-Genis A;Cereijo R;Roca E;Villarroya F
久坐的马拉松运动员面临着强烈的生理挑战。对跑步者生物反应的潜在生物标志物的评估将有助于区分个体的比赛反应及其生理后果。本研究旨在分析马拉松比赛剧烈运动后，运动员血浆中与代谢应激相关的新型内分泌因子GDF 15和FGF 21水平的变化。在马拉松比赛前48 h、比赛后即刻和比赛后48 h，从18名男性跑步者（平均值±标准差，年龄：41.7 ±5.0岁，BMI：23.6 ± 1.8）以及年龄匹配的久坐者中采集血样。测定了GDF 15、FGF 21和38个其他生化和血液学参数的水平。GDF15和FGF21的基础水平在赛前跑步者和久坐者之间没有差异。在比赛结束后立即在跑步者中发现GDF15（4.2倍）和FGF21（20倍）的平均水平显着增加。这些增加的幅度在个体之间差异很大，彼此之间没有相关性。GDF15和FGF21水平在比赛后48小时恢复到基础水平。GDF 15（而不是FGF 21）的赛后值与总白色细胞计数（r = 0.50，P = 0.01）和嗜中性粒细胞（r = 0.10，P = 0.01）的增加呈正相关。在马拉松比赛后，运动员的GDF 15和FGF 21瞬时增加。GDF15水平的诱导与循环免疫细胞水平的改变相关。
Recreational marathon runners face strong physiological challenges. Assessment of potential biomarkers for the biological responses of runners will help to discriminate individual race responsiveness and their physiological consequences. This study sought to analyze the changes in the plasma levels of GDF15 and FGF21, novel endocrine factors related to metabolic stress, in runners following the strenuous exercise of a marathon race. Blood samples were obtained from eighteen male runners (mean ±SD, age: 41.7 ±5.0 years, BMI: 23.6 ± 1.8) 48 h before, immediately after, and 48 h after a marathon race, and from age-matched sedentary individuals. The level of GDF15, FGF21, and 38 additional biochemical and hematological parameters were determined. The basal levels of GDF15 and FGF21 did not differ between runners before the race and sedentary individuals. Significant increases in the mean levels of GDF15 (4.2-fold) and FGF21 (20-fold) were found in runners immediately after the race. The magnitudes of these increases differed markedly among individuals and did not correlate with each other. The GDF15 and FGF21 levels had returned to the basal level 48 h post-race. The post-race value of GDF15 (but not FGF21) correlated positively with increased total white cell count (r = 0.50, P = 0.01) and neutrophilia (r = 0.10, P = 0.01). GDF15 and FGF21 are transiently increased in runners following a marathon race. The induction of GDF15 levels is associated with alterations in circulating immune cells levels.
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影响因子：
3.7
作者：
Kim KH;Kim SH;Min YK;Yang HM;Lee JB;Lee MS
通讯作者：
Lee MS
影响因子：
82.9
作者：
Emmerson, Paul J.;Wang, Feng;Wu, Xinle
通讯作者：
Wu, Xinle
DOI：
10.3390/ijerph17176191
发表时间：
2020-08-26
影响因子：
--
作者：
Kaleta-Duss AM;Lewicka-Potocka Z;Dąbrowska-Kugacka A;Raczak G;Lewicka E
通讯作者：
Lewicka E
影响因子：
4.8
作者：
Fudim, Marat;Kelly, Jacob P.;Felker, G. Michael
通讯作者：
Felker, G. Michael
影响因子：
4.3
作者：
Adela R;Banerjee SK
通讯作者：
Banerjee SK