Naturalistic Topography Assessment in a Randomized Clinical Trial of Smoking Unfiltered Cigarettes: Challenges, Opportunities, and Recommendations.

Naturalistic Topography Assessment in a Randomized Clinical Trial of Smoking Unfiltered Cigarettes: Challenges, Opportunities, and Recommendations.
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DOI:
10.3390/ijerph182211857
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发表时间:
2021-11-12
影响因子:
--
通讯作者:
Oren E
Oren E
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Romero DR;Pulvers K;Carter E;Barber C;Satybaldiyeva N;Novotny TE;Oren E

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吸烟地形图(ST)是一组描述不同环境下吸烟行为特征的测量方法。CReSS便携式设备可以在自然环境中测量ST。没有使用CReSS纵向测量ST的标准方案。本研究探讨了利用CReSS来衡量ST,并强调了在自然环境中的挑战和机遇。这项研究是一项随机交叉临床试验的一部分,试验对象是吸过滤嘴香烟或不吸过滤嘴香烟的人。参与者(n = 43)在每种研究条件下使用CReSS装置在其自然吸烟环境中吸烟两周,持续五天。在洗脱期间对器械进行校准和清洁,每次访视时下载数据。进行5次测试抽吸,以校准每个器械。器械使用的合规率为中等(74.1%),遇到的问题包括过热/堵塞、日期/时间戳数据登记不正确以及器械维修/更换。常规检查/清洁和器械使用培训有助于缓解器械故障。CReSS装置被证明是一种可行的工具,可以检查自然吸烟地形和烟草产品设计变化对吸烟无过滤嘴香烟的潜在影响。这是第一项纵向检查ST变量的研究,在多个时间点测量,并使用无过滤嘴香烟。
Smoking topography (ST) is a set of measures profiling the behavioral characteristics of smoking in various settings. The CReSS portable device can measure ST in the natural environment. No standard protocol exists for measuring ST longitudinally with the CReSS. This study examined the utilization of the CReSS to measure ST and highlights challenges and opportunities in a naturalistic setting. This study is part of a randomized cross-over clinical trial of smoking filtered or unfiltered cigarettes. Participants (n = 43) smoked in each study condition for two weeks using the CReSS device for five days in their naturalistic smoking setting. The devices were calibrated and cleaned during the washout period, and data were downloaded every visit. Five test puffs were administered to calibrate each device. Moderate compliance rates (74.1%) were found with device usage, and the issues encountered were overheating/clogging, incorrectly registered date/time-stamped data, and device repair/replacement. Routine inspection/cleaning and training in device usage were instrumental in mitigating device malfunctioning. The CReSS device proved to be a feasible tool to examine naturalistic smoking topography and the potential impact of changes in tobacco product design on smoking unfiltered cigarettes. This is the first study to examine ST variables longitudinally, measured at multiple time points, and using unfiltered cigarettes.
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