Insights into Exosome in the Intervertebral Disc: Emerging Role for Disc Homeostasis and Normal Function.
Insights into Exosome in the Intervertebral Disc: Emerging Role for Disc Homeostasis and Normal Function.
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DOI：
10.7150/ijms.75285
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发表时间：
2022
影响因子：
3.6
通讯作者：
Ye Z
中科院分区：
文献类型：
--
作者：
Zhao X;Xu B;Duan W;Chang L;Tan R;Sun Z;Ye Z
腰痛（LBP）是一种慢性疾病，给个人带来巨大痛苦和经济负担。腰痛的主要诱因是椎间盘退变（IDD），它是由一系列稳态改变引起的，包括髓核（NP）和纤维环（AF）细胞的凋亡、细胞外基质（ECM）的降解、软骨终板（CEP）的钙化等。目前，IDD的治疗策略包括保守治疗和手术治疗。然而，它们都不能逆转椎间盘的进行性破坏。因此，寻求一种新的治疗方法至关重要。外泌体是一种直径为30- 150nm的纳米级物质，可以由各种类型的细胞合成和分泌。它们在细胞间通讯中起着重要作用。越来越多的证据表明外泌体可以影响细胞内转录活性，从而抑制或加速细胞的增殖和凋亡。因此，它是IDD的一种新的治疗来源。本文主要综述了外泌体在IDD发病和恶化中的作用，以及它们的治疗潜力。
Low back pain (LBP) is a chronic condition that causes great individual suffering and economic burden. The major contributor of LBP is intervertebral disc degeneration (IDD), which is caused by a spectrum of homeostasis alteration, including the apoptosis of nucleus pulposus (NP) and annulus fibrosus (AF) cells, degradation of extracellular matrix (ECM), calcification of cartilaginous endplates (CEP) and so on. Currently, the therapeutic strategy for IDD includes conservative and surgery treatment. Nevertheless, none of them could reverse the progressive destruction of the intervertebral disc. Hence, it is pivotal to pursue a new therapeutic approach. Exosomes, nano-sized substances with diameters of 30-150 nm, can be synthesized and secreted by various types of cells. They play an important role in intercellular communication. Increasing evidence implicates that exosomes could impact the intracellular transcription activities, thereby inhibiting or accelerating the proliferation and apoptosis of cells. Thus, it is a new therapeutic source for IDD. This review chiefly focuses on generalizing and clarifying the roles of exosomes in the onset and deterioration of IDD, and their therapeutic potential.
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影响因子：
--
作者：
Chen KH;Chen CH;Wallace CG;Yuen CM;Kao GS;Chen YL;Shao PL;Chen YL;Chai HT;Lin KC;Liu CF;Chang HW;Lee MS;Yip HK
通讯作者：
Yip HK
影响因子：
14
作者：
Bodin, Aase;Bharadwaj, Shantaram;Zhang, Yuanyuan
通讯作者：
Zhang, Yuanyuan
影响因子：
2.8
作者：
Bonnheim, Noah B.;Wang, Linshanshan;Lazar, Ann A.;Zhou, Jiamin;Chachad, Ravi;Sollmann, Nico;Guo, Xiaojie;Iriondo, Claudia;O'Neill, Conor;Lotz, Jeffrey C.;Link, Thomas M.;Krug, Roland;Fields, Aaron J.
通讯作者：
Fields, Aaron J.
影响因子：
3
作者：
BUCKWALTER, JA
通讯作者：
BUCKWALTER, JA
影响因子：
4.2
作者：
Burgess-Hull AJ;Panlilio LV;Preston KL;Epstein DH
通讯作者：
Epstein DH