Post-traumatic stress disorder: emerging concepts of pharmacotherapy.

Post-traumatic stress disorder: emerging concepts of pharmacotherapy.
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DOI:
10.1517/14728210902972494
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发表时间:
2009-06
影响因子:
3.4
通讯作者:
Risbrough VB
Risbrough VB
中科院分区:
医学3区
文献类型:
--
作者:
Baker DG;Nievergelt CM;Risbrough VB

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创伤后应激障碍(PTSD)可能是由创伤经历引起的,会引发恐惧、无助或恐怖的情绪。大多数人保持无症状或症状迅速解决,但在少数侵入性图像和噩梦中,情感麻木和回避,以及过度觉醒持续数十年。PTSD与精神和医学共病、自杀风险增加以及社会和职业功能不良有关。心理治疗和药物治疗是常见的治疗方法。然而,研究支持认知行为心理疗法的疗效,没有足够的证据明确支持任何特定药物治疗的疗效。迫切需要有效的药物来治疗核心和靶向PTSD症状,并用于预防。本文综述了目前和新兴的药物治疗,推进这些目标。
Posttraumatic stress disorder (PTSD) can result from a traumatic experience that elicits emotions of fear, helpless or horror. Most individuals remain asymptomatic or symptoms quickly resolve, but in a minority intrusive imagery and nightmares, emotional numbing and avoidance, and hyperarousal persist for decades. PTSD is associated with psychiatric and medical co-morbidities, increased risk for suicide, and with poor social and occupational functioning. Psychotherapy and pharmacotherapy are common treatments. Whereas, research supports the efficacy of the cognitive behavioral psychotherapies, there is insufficient evidence to unequivocally support the efficacy of any specific pharmacotherapy. Proven effective pharmacologic agents are sorely needed to treat core and targeted PTSD symptoms, and for prevention. This review describes current and emerging pharmacotherapies that advance these goals.
DOI: 10.1523/jneurosci.21-07-02546.2001
发表时间: 2001-04-01
影响因子: 5.3
作者:
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