The emergence of the calvarial hematopoietic niche in health and disease.

The emergence of the calvarial hematopoietic niche in health and disease.
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DOI:
10.1111/imr.13120
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发表时间:
2022-10
影响因子:
8.7
通讯作者:
--
中科院分区:
医学1区
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--
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最近发现头骨的diploë区域作为骨髓细胞储存库的作用。穿过皮质内颅骨的骨化血管通道的存在为细胞从生态位运输提供了通道,CNS来源的抗原通过血管周围方式通过脑脊液到达生态位,向髓细胞输出信号。本综述将重点介绍这一新兴领域的最新发现,以及这一利基在中枢神经系统衰老和疾病中所起的已知作用。它将进一步强调这些细胞用于运输的血管结构的解剖路线和生理特性,从头骨到脑实质。
The diploë region of skull has recently been discovered to act as a myeloid cell reservoir to the underlying meninges. The presence of ossified vascular channels traversing the inner skull of cortex provides a passageway for the cells to traffic from the niche, and CNS‐derived antigens traveling through cerebrospinal fluid in a perivascular manner reaches the niche to signal myeloid cell egress. This review will highlight the recent findings establishing this burgeoning field along with the known role this niche plays in CNS aging and disease. It will further highlight the anatomical routes and physiological properties of the vascular structures these cells use for trafficking, spanning from skull to brain parenchyma.
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