Abnormal development of cerebral arteries and veins in offspring of experimentally preeclamptic rats: Potential role in perinatal stroke.
Abnormal development of cerebral arteries and veins in offspring of experimentally preeclamptic rats: Potential role in perinatal stroke.
复制标题
实验性子痫前期大鼠的后代脑动静脉发育异常：在围产期卒中中的潜在作用
DOI：
10.1016/j.mad.2021.111491
复制
发表时间：
2021-06
影响因子：
5.3
通讯作者：
Cipolla MJ
中科院分区：
文献类型：
--
作者：
Whitaker EE;Johnson AC;Miller JE;Lindner DP;Cipolla MJ
子痫前期是一种妊娠期高血压疾病，在所有妊娠中高达10%会出现这种并发症，并增加后代发生围产期卒中的风险。这种风险增加的机制尚不清楚，但可能涉及血管功能障碍。本研究的目的是评估实验性子痫前期（ePE）对后代脑血管功能的影响，以阐明这种关联可能的机制。从妊娠第7天开始给母鼠喂食高胆固醇饮食以诱导实验性子痫前期。在出生后第16、23和30天，从ePE母鼠所产的幼鼠中分离出大脑中动脉（MCA）和盖伦静脉（VoG），并与正常妊娠（NP）母鼠所产幼鼠进行比较，在动脉描记仪腔室中对其进行加压研究。测量血清中的炎症和氧化应激标志物。我们的研究结果表明，ePE幼鼠的MCA和VoG结构和功能均发生改变。我们还发现了ePE幼鼠存在全身性炎症和氧化应激的证据。这些发现为子痫前期与围产期卒中的发生或严重程度之间提供了一种潜在的联系。
Preeclampsia, a hypertensive disorder of pregnancy, complicates up to 10% of all pregnancies and increases the risk for perinatal stroke in offspring. The mechanism of this increase is unknown, but may involve vascular dysfunction. The goal of this study was to evaluate the effect of experimental preeclampsia (ePE) on cerebrovascular function in offspring to eludciate a possible mechanism for this association. Dams were fed a high cholesterol diet beginning on day 7 of gestation to induce experimental preeclampsia. Middle cerebral arteries (MCA) and the Vein of Galen (VoG) were isolated from pups from ePE dams and compared to pups from normal pregnant (NP) dams at postnatal days 16, 23, and 30 and studied pressurized in an arteriograph chamber. Markers of inflammation and oxidative stress were measured in serum. Our results suggest altered structure and function in both MCA and VoG of ePE pups. We also found evidence of systemic inflammation and oxidative stress in ePE pups. These findings provide a potential link between preeclampsia and the occurrence or severity of perinatal stroke.
登录
查看更多内容
影响因子：
5.5
作者：
Hubbell, Margaret C.;Semotiuk, Andrew J.;Pearce, William J.
通讯作者：
Pearce, William J.
影响因子：
2.5
作者：
Fugelseth, Drude;Ramstad, Heidi Bente;Staff, Anne Cathrine
通讯作者：
Staff, Anne Cathrine
影响因子：
8.3
作者：
Alexander, BT;Kassab, SE;Granger, JP
通讯作者：
Granger, JP
DOI：
10.1055/s-0036-1584515
发表时间：
2016-08-01
期刊：
Revista Brasileira de Ginecologia e Obstetrícia
影响因子：
--
作者：
Dang, Frances;Croy, B. Anne;Figueiró-Filho, Ernesto A.
通讯作者：
Figueiró-Filho, Ernesto A.
影响因子：
5.6
作者：
Giambrone, Ashtin B.;Logue, Omar C.;Warrington, Junie P.
通讯作者：
Warrington, Junie P.