Hypothalamic vasopressin systems are more sensitive to the long term effects of social defeat in males versus females.
Hypothalamic vasopressin systems are more sensitive to the long term effects of social defeat in males versus females.
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DOI：
10.1016/j.psyneuen.2014.09.009
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发表时间：
2015-01
影响因子：
3.7
通讯作者：
Trainor, B. C.
中科院分区：
文献类型：
--
作者：
Steinman, M. Q.;Laredo, S. A.;Lopez, E. M.;Manning, C. E.;Hao, R. C.;Doig, I. E.;Campi, K. L.;Flowers, A. E.;Knight, J. K.;Trainor, B. C.
关键词：
加压素信号通路在社会行为和应激反应的调节中具有重要作用，被认为是一种有前途的靶向治疗应激诱导的精神障碍的新途径。虽然有证据表明精氨酸加压素（AVP）的行为效应存在性别差异，但很少有数据直接比较男性和女性内源性AVP信号传导的应激效应。本实验采用加州小鼠（Peromyscuscalifornicus），研究了社交失败应激对室旁核（PVN）和终纹后内侧床核（BNSTmp）内AVP免疫反应细胞的短期和长期影响。急性暴露失败增加AVP/c-fos细胞在PVN和SON的男性和女性。相反，失败的长期影响存在性别差异。男性而不是女性暴露于失败的PVN中的AVP mRNA较少，在两个实验中，失败减少了雄性而不是女性尾侧PVN中AVP阳性细胞的数量。有趣的是，在与目标小鼠的相对良性的社会接触期间，雄性而不是雌性的PVN中的AVP染色百分比（包括细胞体和纤维）迅速下降。失败降低了雄性动物的AVP染色百分比，但并未阻断社会诱导的染色百分比降低。当小鼠进行测试的居民入侵者测试，男性暴露于失败的男性不低于控制男性的侵略性，而侵略被废除的女性。然而，发作的侵略与AVP神经元的数量在BNSTmp的控制男性，但不强调男性，这表明不同的机制介导的控制和强调男性的侵略。这些数据表明，虽然男性和女性对失败的急性AVP反应相似，但失败对AVP的长期影响在男性中更强。
Vasopressin signaling has important effects on the regulation of social behaviors and stress responses, and is considered a promising pathway to target for new therapeutics of stress-induced psychiatric disorders. Although there is evidence for sex differences in the behavioral effects of arginine vasopressin (AVP), few data have directly compared the effects of stress on endogenous AVP signaling in males and females. We used California mice (Peromyscus californicus) to study the short and long term effects of social defeat stress on AVP immunoreactive cells in the paraventricular nucleus (PVN) and the posteromedial bed nucleus of the stria terminalis (BNSTmp). Acute exposure to defeat increased AVP/c-fos cells in the PVN and SON of both males and females. In contrast, there were sex differences in the long term effects of defeat. Males but not females exposed to defeat had less avp mRNA in the PVN, and in two experiments defeat reduced the number of AVP positive cells in the caudal PVN of males but not females. Interestingly, during relatively benign social encounters with a target mouse, there was a rapid decrease in AVP percent staining (including cell bodies and fibers) in the PVN of males but not females. Defeat reduced AVP percent staining in males, but did not block the socially induced decrease in percent staining. When mice were tested in resident-intruder tests, males exposed to defeat males were no less aggressive than control males whereas aggression was abolished in females. However, bouts of aggression were positively correlated with the number of AVP neurons in the BNSTmp of control males but not stressed males, suggesting that different mechanisms mediate aggression in control and stressed males. These data show that while acute AVP responses to defeat are similar in males and females, the long term effects of defeat on AVP are stronger in males.
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影响因子：
3
作者：
Greenberg GD;Laman-Maharg A;Campi KL;Voigt H;Orr VN;Schaal L;Trainor BC
通讯作者：
Trainor BC
影响因子：
3.2
作者：
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通讯作者：
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影响因子：
3.7
作者：
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通讯作者：
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影响因子：
3.5
作者：
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通讯作者：
Goodson, James L.