Antiviral IFN-γ responses of monocytes at birth predict respiratory tract illness in the first year of life.
Antiviral IFN-γ responses of monocytes at birth predict respiratory tract illness in the first year of life.
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DOI：
10.1016/j.jaci.2012.02.033
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发表时间：
2012-05
期刊：
影响因子：
--
通讯作者：
Holtzman MJ
中科院分区：
文献类型：
--
作者：
Sumino K;Tucker J;Shahab M;Jaffee KF;Visness CM;Gern JE;Bloomberg GR;Holtzman MJ
病毒性呼吸道感染是婴儿期急性疾病的主要原因，并与生命后期的慢性炎症性气道疾病密切相关。然而，急性呼吸道感染易感性的决定因素仍然需要确定。我们调查了出生时抗病毒反应的个体差异是否决定了出生后第一年患急性呼吸道疾病的风险。我们研究了82名儿童，他们参加了一项出生队列研究，研究对象是父母中至少有一人患有过敏或哮喘的市中心儿童。我们培养了脐带血单核细胞，并在接种呼吸道合胞病毒后24小时评估IFNG和CCL 5 mRNA的产生。我们还每隔3个月监测一次急性呼吸道疾病的频率，并在第一年发病时分析鼻灌洗样本中的呼吸道病毒。88%的受试者报告了呼吸道感染，74%有症状的儿童中回收了呼吸道病毒。我们在人群中观察到脐带血单核细胞的广泛抗病毒反应。此外，呼吸道合胞病毒感染单核细胞后IFNG（而不是CCL 5）mRNA的产生减少与上呼吸道感染的频率显著增加（r =-0.42，P <0.001）以及耳和鼻窦感染、肺炎和泌尿系统相关住院的患病率显著增加相关。对呼吸道病毒的先天免疫反应的个体差异甚至在出生时就可检测到，这些差异预测了生命第一年期间对急性呼吸道疾病的易感性。
Viral respiratory tract infections are the leading cause of acute illness during infancy and are closely linked to chronic inflammatory airway diseases later in life. However, the determinants of susceptibility to acute respiratory tract infections still need to be defined. We investigated whether the individual variation in antiviral response at birth determines the risk for acute respiratory tract illness in the first year of life. We studied 82 children who were enrolled in a birth cohort study of inner-city children with at least 1 parent with allergy or asthma. We cultured cord blood monocytes and assessed IFNG and CCL5 mRNA production at 24 hours after inoculation with respiratory syncytial virus. We also monitored the frequency of acute respiratory tract illness at 3-month intervals and analyzed nasal lavage samples for respiratory tract viruses at the time of illness during the first year. Respiratory tract infection was reported for 88% of subjects, and respiratory tract viruses were recovered in 74% of symptomatic children. We observed a wide range of antiviral responses in cord blood monocytes across the population. Furthermore, a decrease in production of IFNG (but not CCL5) mRNA in response to respiratory syncytial virus infection of monocytes was associated with a significant increase in the frequency of upper respiratory tract infections (r = −0.42, P < .001) and the prevalence of ear and sinus infections, pneumonias, and respiratory-related hospitalizations. Individual variations in the innate immune response to respiratory tract viruses are detectable even at birth, and these differences predict the susceptibility to acute respiratory tract illness during the first year of life.
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DOI：
10.4049/jimmunol.1002456
发表时间：
2010-11-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Cheung DS;Ehlenbach SJ;Kitchens RT;Riley DA;Thomas LL;Holtzman MJ;Grayson MH
通讯作者：
Grayson MH
影响因子：
4.4
作者：
Grayson, Mitchell H.;Ramos, Madeleine S.;Holtzman, Michael J.
通讯作者：
Holtzman, Michael J.
DOI：
10.1164/rccm.200304-499oc
发表时间：
2004-01-01
影响因子：
24.7
作者：
Guerra, S;Lohman, IC;Wright, AL
通讯作者：
Wright, AL
DOI：
10.1164/rccm.200210-1148oc
发表时间：
2003-09-15
影响因子：
24.7
作者：
Legg, JP;Hussain, IR;Warner, JO
通讯作者：
Warner, JO
影响因子：
6.1
作者：
Gehlhar, K;Bilitewski, C;Bufe, A
通讯作者：
Bufe, A