A Decade in Review: A Systematic Review of Universal Influenza Vaccines in Clinical Trials during the 2010 Decade.
A Decade in Review: A Systematic Review of Universal Influenza Vaccines in Clinical Trials during the 2010 Decade.
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评论十年：在2010年的临床试验中对普遍流感疫苗的系统评价。
DOI：
10.3390/v12101186
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发表时间：
2020-10-20
期刊：
影响因子：
--
通讯作者：
Weaver EA
中科院分区：
文献类型：
--
作者：
Corder BN;Bullard BL;Poland GA;Weaver EA
全球每年平均有300万至500万例严重的流感病毒感染病例。季节性流感疫苗对不同流感毒株的保护作用有限。因此，开发通用流感疫苗是NIH的首要任务。在这里，我们报告了2010-2019十年期间在临床试验中测试的所有通用流感疫苗的全面总结。在发现的1597项研究中，69项合格的临床试验，调查了27种疫苗，被纳入本次审查。对每项试验的信息进行了汇编，包括疫苗靶点、疫苗平台、佐剂纳入、临床试验阶段和结果。展望未来，目前有三种疫苗正在进行第三阶段临床试验，它们可能比季节性流感疫苗有重大改进。这篇对2010-2019十年期间通用流感疫苗临床试验的系统性综述提供了改进流感疫苗的最新进展。
On average, there are 3–5 million severe cases of influenza virus infections globally each year. Seasonal influenza vaccines provide limited protection against divergent influenza strains. Therefore, the development of a universal influenza vaccine is a top priority for the NIH. Here, we report a comprehensive summary of all universal influenza vaccines that were tested in clinical trials during the 2010–2019 decade. Of the 1597 studies found, 69 eligible clinical trials, which investigated 27 vaccines, were included in this review. Information from each trial was compiled for vaccine target, vaccine platform, adjuvant inclusion, clinical trial phase, and results. As we look forward, there are currently three vaccines in phase III clinical trials which could provide significant improvement over seasonal influenza vaccines. This systematic review of universal influenza vaccine clinical trials during the 2010–2019 decade provides an update on the progress towards an improved influenza vaccine.
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影响因子：
7.3
作者：
Chen X;Liu S;Goraya MU;Maarouf M;Huang S;Chen JL
通讯作者：
Chen JL
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DOI：
10.1038/mt.2013.284
发表时间：
2014-03
期刊：
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影响因子：
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作者：
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影响因子：
9.2
作者：
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通讯作者：
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