Anticholinergic Medication and Caries Status Predict Xerostomia under 65.
Anticholinergic Medication and Caries Status Predict Xerostomia under 65.
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DOI：
10.3390/dj11040087
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发表时间：
2023-03-23
影响因子：
2.6
通讯作者：
中科院分区：
文献类型：
--
作者：
抗胆碱能药物在年轻人中的使用正在增加，但关于口干症的信息有限，口干症是最常见的抗胆碱能副作用。这项病例对照回顾研究考察了18至65岁成年人中抗胆碱能药物引起的口干症与龋齿状况之间的关系。研究样本包括649名口干症患者和649名年龄和性别匹配的对照组。用抗胆碱能药物量表(ADS)评估抗胆碱能负荷量。通过计算龋齿缺失充填指数(DMFT)记录患龋率。口干症患者的平均DMFT指数(16.02±9.50)高于年龄和性别匹配的非口干症对照组(分别为13.83±8.83和1.89±2.45)，这与药物的抗胆碱能暴露水平(3.26±2.81)相对应。Logistic回归分析验证了DMFT、AC用药总数和ADS负担对口干症状况的影响。比较患有口干症和不患有口干症的成年人，发现在几个危险因素上存在统计学差异，如吸烟、糖尿病、睡眠呼吸暂停和抗胆碱能药物的使用。个人化的牙科护理计划应该包括评估药物的抗胆碱能负担，而不考虑患者的年龄，以防止龋病加重。
The use of anticholinergic medications is increasing in younger ages, yet information about xerostomia, the most common anticholinergic side effect, is limited. This case–control retrospective study examines the relationship between anticholinergic medication-induced xerostomia and caries status among adults between 18 and 65 years of age. The study sample comprised 649 cases with xerostomia and 649 age- and gender-matched controls. The anticholinergic burden was estimated using the anticholinergic drug scale (ADS). Caries experience was recorded by calculating the Decayed, Missing, Filled Tooth (DMFT) index. Individuals with xerostomia had a higher mean DMFT index (16.02 ± 9.50), which corresponded with a higher level of anticholinergic exposure from medications (3.26 ± 2.81) compared to their age and gender-matched controls without xerostomia (13.83 + 8.83 and 1.89 ± 2.45, respectively). Logistic regression analysis verified the effects of DMFT, the total number of AC medications, and the ADS burden on xerostomia status. Comparing adults with or without xerostomia revealed statistical differences in several risk factors, such as smoking, diabetes, sleep apnea, and the utilization of anticholinergic medications. A personalized dental care plan should include the evaluation of the anticholinergic burden from medications regardless of the patient’s age to prevent increased caries severity.
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影响因子：
2.1
作者：
Chapuis, Justine;Siu-Paredes, Francesca;Denis, Frederic
通讯作者：
Denis, Frederic
DOI：
10.1016/j.oooo.2021.08.015
发表时间：
2021-12
影响因子：
2.9
作者：
Arany, Szilvia;Kopycka-Kedzierawski, Dorota T.;Caprio, Thomas, V;Watson, Gene E.
通讯作者：
Watson, Gene E.
影响因子：
6
作者：
Ferrari, Anna;Baraldi, Carlo;Rustichelli, Cecilia
通讯作者：
Rustichelli, Cecilia
影响因子：
6.4
作者：
Lagerberg, Tyra;Molero, Y.;Chang, Z.
通讯作者：
Chang, Z.
影响因子：
--
作者：
Agostini, Bernardo Antonio;Cericato, Graziela Oro;Demarco, Flavio Fernando
通讯作者：
Demarco, Flavio Fernando