Social status alters defeat-induced neural activation in Syrian hamsters.
Social status alters defeat-induced neural activation in Syrian hamsters.
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DOI：
10.1016/j.neuroscience.2012.03.002
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发表时间：
2012-05-17
期刊：
影响因子：
3.3
通讯作者：
Cooper, M. A.
中科院分区：
文献类型：
--
作者：
Morrison, K. E.;Curry, D. W.;Cooper, M. A.
虽然暴露于社会压力会导致抑郁样和焦虑样行为的增加，但有些人比其他人更容易受到这些压力引起的行为变化的影响。先前的社会经验是一个因素，可以调节个人如何应对压力事件。在这项研究中，我们调查是否经验依赖性的社会失败的行为后果的阻力与特定的神经激活模式。我们将体重匹配的雄性叙利亚仓鼠配对，每天进行两周的攻击性接触，在此期间，它们形成了稳定的优势关系。我们还包括每天暴露于空笼中两周的对照组。在最后一次配对或空笼暴露后24小时，一半的受试者在3分钟、5分钟的遭遇中被社会击败，而其他受试者没有被社会击败。社交失败后24小时，在与非攻击性入侵者的5分钟社交互动测试中测试动物的条件性失败。我们收集了社交失败后的大脑，并对组织进行了c-Fos免疫反应性处理。我们发现，主导者更有可能反击居民的侵略者在社会失败比下属，他们表现出较少的顺从和防御行为在条件性失败测试相比，下属。此外，社会地位与特定大脑区域（包括杏仁核、前额叶皮质、下丘脑和外侧隔）中失败诱导的神经激活的不同模式有关。我们的研究结果表明，社会地位是一个重要的形式，先前的经验，预测最初的应对方式和社会失败的抵抗程度。此外，失败诱导的神经激活的差异表明，可能的大脑区域，可能控制阻力的条件性失败在占主导地位的个人。
While exposure to social stress leads to increased depression-like and anxiety-like behavior, some individuals are more vulnerable than others to these stress-induced changes in behavior. Prior social experience is one factor that can modulate how individuals respond to stressful events. In this study we investigated whether experience-dependent resistance to the behavioral consequences of social defeat was associated with a specific pattern of neural activation. We paired weight-matched male Syrian hamsters in daily aggressive encounters for two weeks, during which they formed a stable dominance relationship. We also included controls that were exposed to an empty cage each day for two weeks. Twenty-four hours after the final pairing or empty cage exposure, half of the subjects were socially defeated in 3, 5-min encounters, while the others were not socially defeated. Twenty-four hours after social defeat, animals were tested for conditioned defeat in a 5-min social interaction test with a non-aggressive intruder. We collected brains following social defeat and processed tissue for c-Fos immunoreactivity. We found that dominants were more likely to counter-attack the resident aggressor during social defeat than were subordinates, and they showed less submissive and defensive behavior at conditioned defeat testing compared to subordinates. Also, social status was associated with distinct patterns of defeat-induced neural activation in select brain regions including the amygdala, prefrontal cortex, hypothalamus, and lateral septum. Our results indicate that social status is an important form of prior experience that predicts both initial coping style and the degree of resistance to social defeat. Further, the differences in defeat-induced neural activation suggest possible brain regions that may control resistance to conditioned defeat in dominant individuals.
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影响因子：
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通讯作者：
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