Later-life sleep, cognition, and neuroimaging research: an update for 2020.

Later-life sleep, cognition, and neuroimaging research: an update for 2020.
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DOI:
10.1016/j.cobeha.2019.12.011
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发表时间:
2020-06
影响因子:
5
通讯作者:
Spira AP
Spira AP
中科院分区:
心理学2区
文献类型:
--
作者:
Alfini AJ;Tzuang M;Owusu JT;Spira AP

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这篇综述总结了晚年睡眠和大脑健康的最新研究,重点关注认知和磁共振成像 (MRI) 衍生的结果。大多数老年人都存在睡眠问题,其中超过三分之一患有睡眠呼吸障碍 (SDB)。本文描述的研究建立在证明异常睡眠持续时间、睡眠碎片化和 SDB 与记忆障碍和执行功能障碍相关的工作的基础上。自我报告的睡眠不足与皮质变薄和白质完整性降低有关,客观测量的碎片化和 SDB 与灰质萎缩和连接性改变有关。结果表明,大脑变化介导了先前发现的睡眠与认知的关联。需要进行更多的临床试验来确定治疗失眠或 SDB 是否有益于该人群的认知能力。
This review summarizes recent studies of sleep and brain health in later life, focusing on cognitive and magnetic resonance imaging (MRI)-derived outcomes. The majority of older people report sleep problems, and over one-third have sleep-disordered breathing (SDB). The research described herein builds on work demonstrating that abnormal sleep duration, sleep fragmentation, and SDB are associated with memory impairment and executive dysfunction. Self-reported short sleep is linked with greater cortical thinning and lower white matter integrity, and objectively measured fragmentation and SDB are tied to gray matter atrophy and altered connectivity. Results suggest that brain changes mediate previously identified sleep-cognition associations. Additional clinical trials are needed to determine whether treating insomnia or SDB benefits cognition in this population.
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