Acupuncture for visceral pain: neural substrates and potential mechanisms.
Acupuncture for visceral pain: neural substrates and potential mechanisms.
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针灸治疗内脏疼痛：神经基质和潜在机制
DOI：
10.1155/2014/609594
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Chen S;Wang S;Rong P;Wang J;Qiao L;Feng X;Liu J;Zhang J
内脏疼痛是各种疾病引起的最常见的疼痛形式，也是患者寻求医疗咨询的主要原因。尽管取得了很大进展，但与其躯体对应物相比，其病理生理机制仍然知之甚少，因此，治疗效果通常不令人满意。针灸长期以来一直用于治疗许多疾病，特别是疼痛和内脏疼痛，其特点是高治疗效益和低副作用。先前的研究结果表明，针灸通过激活中枢和外周的一些神经递质或调节剂，包括阿片肽、5-羟色胺、去甲肾上腺素和腺苷来抑制疼痛。这为我们深入了解离子通道和肠道微生物群在疼痛过程中的作用提供了新的视角，有助于我们进一步探讨针刺镇痛的机制。在本文中，我们描述了内脏神经支配和相关的传入途径，特别是离子通道在内脏伤害性感受，提出了三个主要机制负责针刺诱导的内脏疼痛的好处。最后，对该领域未来的研究方向进行了展望。
Visceral pain is the most common form of pain caused by varied diseases and a major reason for patients to seek medical consultation. Despite much advances, the pathophysiological mechanism is still poorly understood comparing with its somatic counterpart and, as a result, the therapeutic efficacy is usually unsatisfactory. Acupuncture has long been used for the management of numerous disorders in particular pain and visceral pain, characterized by the high therapeutic benefits and low adverse effects. Previous findings suggest that acupuncture depresses pain via activation of a number of neurotransmitters or modulators including opioid peptides, serotonin, norepinephrine, and adenosine centrally and peripherally. It endows us, by advancing the understanding of the role of ion channels and gut microbiota in pain process, with novel perspectives to probe the mechanisms underlying acupuncture analgesia. In this review, after describing the visceral innervation and the relevant afferent pathways, in particular the ion channels in visceral nociception, we propose three principal mechanisms responsible for acupuncture induced benefits on visceral pain. Finally, potential topics are highlighted regarding the future studies in this field.
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DOI：
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发表时间：
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期刊：
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影响因子：
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