Characterizing the impact of adversity, abuse, and neglect on adolescent amygdala resting-state functional connectivity.
Characterizing the impact of adversity, abuse, and neglect on adolescent amygdala resting-state functional connectivity.
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描述逆境、虐待和忽视对青少年杏仁核静息态功能连接的影响。
DOI：
10.1016/j.dcn.2020.100894
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发表时间：
2021-03
影响因子：
4.7
通讯作者：
Mackiewicz Seghete KL
中科院分区：
文献类型：
--
作者：
Cheng TW;Mills KL;Miranda Dominguez O;Zeithamova D;Perrone A;Sturgeon D;Feldstein Ewing SW;Fisher PA;Pfeifer JH;Fair DA;Mackiewicz Seghete KL
描述童年逆境的类型学可以为制定风险简介和旨在减轻其终身后果的相应干预措施提供信息。这些类型学的神经生物学基础需要系统地比较具有不同暴露历史的个体之间的神经结构和功能。本研究使用种子到全脑分析，在三项独立研究（N = 223; 127逆境组）中，在逆境的一般和维度模型（比较虐待和忽视）中，研究了11-19岁青少年的童年逆境和杏仁核静息态功能连接（rs-fc）之间的关联。在一般模型中，逆境与杏仁核rs-fc的改变有关，杏仁核rs-fc在左前外侧前额叶皮质内具有簇。在一个维度模型中，滥用与眶额皮质、背侧楔前叶、后扣带回皮质和背侧前扣带回皮质/前中扣带回皮质以及背侧注意力、视觉和躯体运动网络内杏仁核RS-FC的改变相关。神经元与杏仁核rs-fc改变与海马，辅助运动皮层，颞顶连接，和区域内的背侧注意力网络。一般和维度模型都揭示了独特的区域，潜在地反映了不同的逆境历史可能影响青少年行为，认知和精神病理学的途径。
Characterizing typologies of childhood adversity may inform the development of risk profiles and corresponding interventions aimed at mitigating its lifelong consequences. A neurobiological grounding of these typologies requires systematic comparisons of neural structure and function among individuals with different exposure histories. Using seed-to-whole brain analyses, this study examined associations between childhood adversity and amygdala resting-state functional connectivity (rs-fc) in adolescents aged 11–19 years across three independent studies (N = 223; 127 adversity group) in both general and dimensional models of adversity (comparing abuse and neglect). In a general model, adversity was associated with altered amygdala rs-fc with clusters within the left anterior lateral prefrontal cortex. In a dimensional model, abuse was associated with altered amygdala rs-fc within the orbitofrontal cortex, dorsal precuneus, posterior cingulate cortex, and dorsal anterior cingulate cortex/anterior mid-cingulate cortex, as well as within the dorsal attention, visual, and somatomotor networks. Neglect was associated with altered amygdala rs-fc with the hippocampus, supplementary motor cortex, temporoparietal junction, and regions within the dorsal attention network. Both general and dimensional models revealed unique regions, potentially reflecting pathways by which distinct histories of adversity may influence adolescent behavior, cognition, and psychopathology.
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影响因子：
5.6
作者：
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通讯作者：
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影响因子：
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影响因子：
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作者：
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通讯作者：
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影响因子：
4.8
作者：
Bernstein, DP;Stein, JA;Zule, W
通讯作者：
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