Bi-directional regulation of cognitive control by distinct prefrontal cortical output neurons to thalamus and striatum.
Bi-directional regulation of cognitive control by distinct prefrontal cortical output neurons to thalamus and striatum.
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DOI：
10.1038/s41467-021-22260-7
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发表时间：
2021-03-31
影响因子：
16.6
通讯作者：
Mansvelder HD
中科院分区：
文献类型：
--
作者：
de Kloet SF;Bruinsma B;Terra H;Heistek TS;Passchier EMJ;van den Berg AR;Luchicchi A;Min R;Pattij T;Mansvelder HD
内侧前额叶皮层（mPFC）控制目标导向的行为并抑制不适当的行为。背侧和腹侧mPFC （dmPFC/vmPFC）回路在认知控制中具有不同的作用，但其潜在机制尚不清楚。本研究采用神经解剖示踪技术、体外电生理学、化学遗传学和纤维光度法对参与5个选择系列反应时间任务的大鼠进行研究，以表征dmPFC和vmPFC对不同丘脑和纹状体亚域的输出。我们在mPFC中确定了四个空间分离的投射神经元群体。利用纤维光度法，我们发现这些投影明显地编码了行为。突触后纹状体和丘脑神经元处理来自dmPFC和vmPFC的突触输入的差异，突出了潜在的放大行为认知控制的不同途径的机制。dmPFC和vmPFC向丘脑外侧亚区和内侧中背亚区投射的化学发生沉默相反地调节认知控制。此外，投射到纹状体和丘脑的dmPFC神经元分散调节认知控制。总的来说，我们表明mPFC输出通路针对解剖学和功能上不同的纹状体和丘脑亚区编码认知控制的双向命令。本研究提出了一个解剖，神经生理和功能特征的四个不同的前额叶群体，投射到纹状体和丘脑次区域。作者表明，这些人群中的每一个在认知控制的调节中都有独立的作用。
The medial prefrontal cortex (mPFC) steers goal-directed actions and withholds inappropriate behavior. Dorsal and ventral mPFC (dmPFC/vmPFC) circuits have distinct roles in cognitive control, but underlying mechanisms are poorly understood. Here we use neuroanatomical tracing techniques, in vitro electrophysiology, chemogenetics and fiber photometry in rats engaged in a 5-choice serial reaction time task to characterize dmPFC and vmPFC outputs to distinct thalamic and striatal subdomains. We identify four spatially segregated projection neuron populations in the mPFC. Using fiber photometry we show that these projections distinctly encode behavior. Postsynaptic striatal and thalamic neurons differentially process synaptic inputs from dmPFC and vmPFC, highlighting mechanisms that potentially amplify distinct pathways underlying cognitive control of behavior. Chemogenetic silencing of dmPFC and vmPFC projections to lateral and medial mediodorsal thalamus subregions oppositely regulate cognitive control. In addition, dmPFC neurons projecting to striatum and thalamus divergently regulate cognitive control. Collectively, we show that mPFC output pathways targeting anatomically and functionally distinct striatal and thalamic subregions encode bi-directional command of cognitive control. This study presents an anatomical, neurophysiological and functional characterization of four distinct prefrontal populations that project to striatal and thalamic sub-regions. The authors show that each of these populations have a discrete role in the regulation of cognitive control.
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影响因子：
16.6
作者：
de Kloet SF;Bruinsma B;Terra H;Heistek TS;Passchier EMJ;van den Berg AR;Luchicchi A;Min R;Pattij T;Mansvelder HD
通讯作者：
Mansvelder HD
影响因子：
64.8
作者：
Harris JA;Mihalas S;Hirokawa KE;Whitesell JD;Choi H;Bernard A;Bohn P;Caldejon S;Casal L;Cho A;Feiner A;Feng D;Gaudreault N;Gerfen CR;Graddis N;Groblewski PA;Henry AM;Ho A;Howard R;Knox JE;Kuan L;Kuang X;Lecoq J;Lesnar P;Li Y;Luviano J;McConoughey S;Mortrud MT;Naeemi M;Ng L;Oh SW;Ouellette B;Shen E;Sorensen SA;Wakeman W;Wang Q;Wang Y;Williford A;Phillips JW;Jones AR;Koch C;Zeng H
通讯作者：
Zeng H
影响因子：
9.2
作者：
Hardung, Stefanie;Epple, Robert;Diester, Ilka
通讯作者：
Diester, Ilka
影响因子：
3.4
作者：
Feja, Malte;Koch, Michael
通讯作者：
Koch, Michael
DOI：
10.1126/science.aac9698
发表时间：
2016-01-01
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Ferenczi EA;Zalocusky KA;Liston C;Grosenick L;Warden MR;Amatya D;Katovich K;Mehta H;Patenaude B;Ramakrishnan C;Kalanithi P;Etkin A;Knutson B;Glover GH;Deisseroth K
通讯作者：
Deisseroth K