Schwann cell-specific JAM-C-deficient mice reveal novel expression and functions for JAM-C in peripheral nerves.
Schwann cell-specific JAM-C-deficient mice reveal novel expression and functions for JAM-C in peripheral nerves.
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DOI：
10.1096/fj.11-196220
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发表时间：
2012-03
期刊：
影响因子：
--
通讯作者：
Nourshargh S
中科院分区：
文献类型：
--
作者：
Colom B;Poitelon Y;Huang W;Woodfin A;Averill S;Del Carro U;Zambroni D;Brain SD;Perretti M;Ahluwalia A;Priestley JV;Chavakis T;Imhof BA;Feltri ML;Nourshargh S
连接粘附分子-C (JAM-C) 是一种在相邻内皮细胞和上皮细胞之间的连接处表达的粘附分子，与多种炎症和血管反应有关。此外，我们最近报道了雪旺细胞 (SC) 中 JAM-C 的表达及其对周围神经完整性和功能的重要性。为了进一步研究 JAM-C 在神经元功能中的作用，产生了 SC 中 JAM-C 特异性缺失的小鼠 (JAM-C SC KO)。与野生型 (WT) 对照相比，JAM-C SC KO 小鼠表现出电生理缺陷、肌肉无力和对机械刺激过敏。在解决这些缺陷的根本原因时，发现 JAM-C SC KO 小鼠的神经在结旁区域存在形态缺陷，与 WT 相比，结节长度增加。该研究还报告了以前未检测到的 JAM-C 表达，即在神经周围细胞上的表达，与 JAM-C SC KO 动物的伤害感受缺陷一致，在细髓鞘感觉神经纤维上的表达。总的来说，JAM-C SC KO 小鼠的产生和表征为 SC JAM-C 参与周围神经的精细组织和调节多个神经元反应提供了明确的证据。-Colom, B.、Poitelon, Y.、Huang, W.、Woodfin, A.、Averill, S.、Del Carro, U.、Zambroni, D.、Brain, S. D.、Perretti, M., Ahluwalia, A.、Priestley, J. V.、Chavakis, T.、Imhof, B. A.、Feltri, M. L.、Nourshargh, S. Schwann 细胞特异性 JAM-C 缺陷小鼠揭示了 JAM-C 在周围神经中的新表达和功能。
Junctional adhesion molecule-C (JAM-C) is an adhesion molecule expressed at junctions between adjacent endothelial and epithelial cells and implicated in multiple inflammatory and vascular responses. In addition, we recently reported on the expression of JAM-C in Schwann cells (SCs) and its importance for the integrity and function of peripheral nerves. To investigate the role of JAM-C in neuronal functions further, mice with a specific deletion of JAM-C in SCs (JAM-C SC KO) were generated. Compared to wild-type (WT) controls, JAM-C SC KO mice showed electrophysiological defects, muscular weakness, and hypersensitivity to mechanical stimuli. In addressing the underlying cause of these defects, nerves from JAM-C SC KO mice were found to have morphological defects in the paranodal region, exhibiting increased nodal length as compared to WTs. The study also reports on previously undetected expressions of JAM-C, namely on perineural cells, and in line with nociception defects of the JAM-C SC KO animals, on finely myelinated sensory nerve fibers. Collectively, the generation and characterization of JAM-C SC KO mice has provided unequivocal evidence for the involvement of SC JAM-C in the fine organization of peripheral nerves and in modulating multiple neuronal responses.—Colom, B., Poitelon, Y., Huang, W., Woodfin, A., Averill, S., Del Carro, U., Zambroni, D., Brain, S. D., Perretti, M., Ahluwalia, A., Priestley, J. V., Chavakis, T., Imhof, B. A., Feltri, M. L., Nourshargh, S. Schwann cell-specific JAM-C-deficient mice reveal novel expression and functions for JAM-C in peripheral nerves.
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