Course of the sFlt-1/PlGF ratio in fetal growth restriction and correlation with biometric measurements, feto-maternal Doppler parameters and time to delivery.
Course of the sFlt-1/PlGF ratio in fetal growth restriction and correlation with biometric measurements, feto-maternal Doppler parameters and time to delivery.
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DOI：
10.1007/s00404-021-06186-5
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发表时间：
2022-03
影响因子：
2.6
通讯作者：
Köninger A
中科院分区：
文献类型：
--
作者：
Andrikos A;Andrikos D;Schmidt B;Birdir C;Kimmig R;Gellhaus A;Köninger A
该研究旨在评估胎儿生长受限（FGR）孕妇可溶性fms样酪氨酸激酶1 (sFlt-1)/胎盘生长因子（PlGF）比值的过程，并评估sFlt-1/PlGF比值与胎母多普勒参数、胎儿生物特征测量以及研究纳入和出生之间的时间（“分娩时间”）之间的潜在关联。这是一项回顾性纵向单中心研究，包括52例FGR病例。采用BRAHMS Kryptor Compact PLUS检测血清sFlt-1和PlGF水平。胎儿生物特征和多普勒参数，以及sFlt-1/PlGF比值，在研究纳入时和出生时均获得。FGR患者纳入研究时和出生时母体血液中生物标志物水平与超声参数之间存在各种相关性：脐动脉（p < 0.01）、子宫动脉（p < 0.01）、静脉导管（p < 0.05）、脑胎盘比（CPR） （p < 0.01）、股骨长度（p < 0.01）和出生体重（p < 0.01）。纳入研究时，sFlt-1/PlGF比值越高，“分娩时间”越短（p < 0.01）。多因素回归分析显示，血管生成标志物日升高百分比越大，“分娩时间”越短（p < 0.01）。通过母婴多普勒参数（如心肺复苏术）和胎盘功能障碍的严重程度（如分娩紧迫性和出生体重）来衡量的胎儿健康状况，可以通过母体血清中sFlt-1/PlGF比值的水平来反映。sFlt-1/PlGF比值的每日快速增加与疾病的临床进展显著相关。
The study aimed to assess the course of the soluble Fms-like tyrosine kinase 1 (sFlt-1)/placental growth factor (PlGF) ratio in pregnant women with fetal growth restriction (FGR) and to evaluate potential associations between the sFlt-1/PlGF ratio and feto-maternal Doppler parameters, fetal biometric measurements and the time between study inclusion and birth (“time to delivery”). This was a retrospective longitudinal single center study including 52 FGR cases. The serum levels of sFlt-1 and PlGF were measured by using the BRAHMS Kryptor Compact PLUS. Fetal biometric and Doppler parameters, as well as the sFlt-1/PlGF ratio, were obtained both upon study inclusion and upon birth. Various associations between the levels of the biomarkers in maternal blood upon study inclusion and upon birth and sonographic parameters were observed in FGR cases: umbilical artery (p < 0.01), uterine arteries (p < 0.01), ductus venosus (p < 0.05), cerebroplacental ratio (CPR) (p < 0.01), femur length (p < 0.01) and birth weight (p < 0.01). The higher the sFlt-1/PlGF ratio upon study inclusion, the shorter the “time to delivery” (p < 0.01). The multivariate regression analysis showed that the greater the daily percentage increase of the angiogenic markers, the shorter the “time to delivery” (p < 0.01). The fetal well-being, as measured by feto-maternal Doppler parameters such as CPR and the severity of the placental dysfunction, as measured by the urgency of birth and birth weight, is reflected by the level of the sFlt-1/PlGF ratio in the maternal serum. A rapid daily increase of the sFlt-1/PlGF ratio is significantly associated with the clinical progression of the disease.
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影响因子：
5.6
作者：
Herraiz I;Simón E;Gómez-Arriaga PI;Martínez-Moratalla JM;García-Burguillo A;Jiménez EA;Galindo A
通讯作者：
Galindo A
影响因子：
7.1
作者：
Stepan, H.;Herraiz, I.;Schlembach, D.;Verlohren, S.;Brennecke, S.;Chantraine, F.;Klein, E.;Lapaire, O.;Llurba, E.;Ramoni, A.;Vatish, M.;Wertaschnigg, D.;Galindo, A.
通讯作者：
Galindo, A.
影响因子：
7.2
作者：
Herraiz, Ignacio;Droege, Lisa Antonia;Verlohren, Stefan
通讯作者：
Verlohren, Stefan
影响因子：
9.8
作者：
Verlohren, Stefan;Herraiz, Ignacio;Stepan, Holger
通讯作者：
Stepan, Holger
影响因子：
3.7
作者：
Hagmann, Henning;Bossung, Verena;Brinkkoetter, Paul T.
通讯作者：
Brinkkoetter, Paul T.