Reduced prevalence of SARS-CoV-2 infection in ABO blood group O.
Reduced prevalence of SARS-CoV-2 infection in ABO blood group O.
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DOI：
10.1182/bloodadvances.2020002657
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发表时间：
2020-10-27
期刊：
影响因子：
7.5
通讯作者：
Barington T
中科院分区：
文献类型：
--
作者：
Barnkob MB;Pottegård A;Støvring H;Haunstrup TM;Homburg K;Larsen R;Hansen MB;Titlestad K;Aagaard B;Møller BK;Barington T
O型血与降低感染SARS-CoV-2的风险有关。确定感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）后感染和发展严重疾病的风险因素至关重要。在这里，我们对2020年2月27日至2020年7月30日期间检测SARS-CoV-2的所有丹麦个体进行了回顾性队列分析，已知ABO和RhD血型，以确定常见血型对病毒易感性的影响。血型的分布与非测试个体的数据进行了比较。参与者（29%为男性）包括473654名使用实时聚合酶链反应检测SARS-CoV-2的个体（7422例阳性和466232例阴性）和2204742名未检测个体，占丹麦总人口的38%。对于确诊的感染病例，还收集了COVID-19导致的住院和死亡、年龄、心血管合并症和工作状况。ABO血型在患者与对照组之间差异显著，仅38.41%（95%置信区间[CI]，37.30-39.50），而O型血患者为41.70%，（95% CI，41.60-41.80），对应于获得COVID-19的相对风险为0.87（95% CI，0.83-0.91）。这项研究确定ABO血型是SARS-CoV-2感染的风险因素，但不是COVID-19住院或死亡的风险因素。
Blood group O is associated with a decreased risk for contracting SARS-CoV-2 infection. Identification of risk factors for contracting and developing serious illness following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is of paramount interest. Here, we performed a retrospective cohort analysis of all Danish individuals tested for SARS-CoV-2 between 27 February 2020 and 30 July 2020, with a known ABO and RhD blood group, to determine the influence of common blood groups on virus susceptibility. Distribution of blood groups was compared with data from nontested individuals. Participants (29% of whom were male) included 473 654 individuals tested for SARS-CoV-2 using real-time polymerase chain reaction (7422 positive and 466 232 negative) and 2 204 742 nontested individuals, accounting for ∼38% of the total Danish population. Hospitalization and death from COVID-19, age, cardiovascular comorbidities, and job status were also collected for confirmed infected cases. ABO blood groups varied significantly between patients and the reference group, with only 38.41% (95% confidence interval [CI], 37.30-39.50) of the patients belonging to blood group O compared with 41.70% (95% CI, 41.60-41.80) in the controls, corresponding to a relative risk of 0.87 (95% CI, 0.83-0.91) for acquiring COVID-19. This study identifies ABO blood group as a risk factor for SARS-CoV-2 infection but not for hospitalization or death from COVID-19.
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影响因子：
6.4
作者：
Hutson, AM;Atmar, RL;Estes, MK
通讯作者：
Estes, MK
影响因子：
7.5
作者：
Klok, F. A.;Kruip, M. J. H. A.;Endeman, H.
通讯作者：
Endeman, H.
DOI：
10.1001/jama.2020.6775
发表时间：
2020-01-01
期刊：
JAMA, Journal of the American Medical Association
影响因子：
--
作者：
Richardson, Safiya;Hirsch, Jamie S.;,
通讯作者：
,
影响因子：
37.8
作者：
Vasan, Senthil K.;Rostgaard, Klaus;Edgren, Gustaf
通讯作者：
Edgren, Gustaf
影响因子：
20.3
作者：
Neil, SJD;McKnight, A;Weiss, RA
通讯作者：
Weiss, RA