Risk of breast cancer and family history of other cancers in first-degree relatives in Chinese women: a case control study.
Risk of breast cancer and family history of other cancers in first-degree relatives in Chinese women: a case control study.
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中国女性一级亲属患乳腺癌的风险和其他癌症家族史：病例对照研究
DOI：
10.1186/1471-2407-14-662
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发表时间：
2014-09-11
期刊：
影响因子：
3.8
通讯作者：
Wang S
中科院分区：
文献类型：
--
作者：
Zhou W;Ding Q;Pan H;Wu N;Liang M;Huang Y;Chen L;Zha X;Liu X;Wang S
背景很少有研究系统地报道乳腺癌风险与其他癌症家族史之间的关系。方法2006年1月至2011年6月，823例乳腺癌患者为研究对象，年龄匹配的乳腺良性疾病患者为对照组。一级亲属的其他癌症家族史由训练有素的评审员记录。结果在一级亲属中，食道癌(OR：2.70，95%CI：1.11~6.57)、肺癌(OR：2.49，95%CI：1.10~5.65)、消化系统癌(OR：1.79，95%CI：1.14~2.79)、任何癌症(OR：2.13，95%CI：1.49~3.04)家族史与乳腺癌危险性直接相关。在亚组分析中，有肺癌家族史者患激素受体阳性乳腺癌的风险增加(OR：3.37，95%CI：1.45~7.82)，而有食道癌家族史者(OR：6.19，95%CI：2.30~16.71)、子宫癌家族史者(OR：6.92，95%CI：1.12~42.89)、消化道癌家族史者(OR：2.05，95%CI：1.03~4.10)和妇科肿瘤(OR：6.79，95%CI：1.46~31.65)。此外，50岁及以下有消化系统癌家族史的人患乳腺癌的比例显著增加(OR：1.88，95%CI：1.03~3.43)，而50岁以上的人患乳腺癌的家族史较少(OR：1.67，95%CI：0.86~3.25)。其他癌症家族史的影响似乎更可能局限于激素受体阴性的乳腺癌。
BackgroundFew studies have systematically reported the relationship between the risk of breast cancer and family history of other cancers. This study was designed to systematically determine the relationship between breast cancer risk and family history of other cancers in first-degree relatives.MethodsBetween January 2006 and June 2011, 823 women diagnosed with breast cancer were included, and age-matched women diagnosed with benign breast disease were selected as controls. Family history of other cancers in first-degree relatives was recorded by trained reviewers. Multivariate logistic regression was applied to analyze the relationships.ResultsA family history of esophagus cancer (OR: 2.70, 95% CI: 1.11 – 6.57), lung cancer (OR: 2.49 95% CI: 1.10 – 5.65), digestive system cancer (OR: 1.79, 95% CI: 1.14 – 2.79) and any cancer (OR: 2.13, 95% CI: 1.49 – 3.04) in first-degree relatives was directly associated with increased breast cancer risk. In subgroup analysis, the risk of hormone receptor positive breast cancer was increased in subjects with a family history of lung cancer (OR: 3.37, 95% CI: 1.45 – 7.82), while the risk of hormone receptor negative breast cancer was increased in subjects with a family history of esophagus cancer (OR: 6.19, 95% CI: 2.30 – 16.71), uterus cancer (OR: 6.92, 95% CI: 1.12 – 42.89), digestive tract cancer (OR: 2.05, 95% CI: 1.03 – 4.10) and gynecology cancer (OR: 6.79, 95% CI: 1.46 – 31.65). Additionally, a significant increase in breast cancer was observed with a family history of digestive system cancer for subjects 50 y and younger (OR: 1.88, 95% CI: 1.03 – 3.43), not for subjects 50 y older (OR: 1.67, 95% CI: 0.86 – 3.25).ConclusionsBreast cancer aggregates in families with several types of cancer especially for digestive system cancer. The influence of a family history of other cancers seems more likely to be limited to hormone receptor negative breast cancer.
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