Distributed representation of pelvic floor muscles in human motor cortex.
Distributed representation of pelvic floor muscles in human motor cortex.
复制标题
DOI：
10.1038/s41598-018-25705-0
复制
发表时间：
2018-05-08
影响因子：
4.6
通讯作者：
Kutch JJ
中科院分区：
文献类型：
--
作者：
Yani MS;Wondolowski JH;Eckel SP;Kulig K;Fisher BE;Gordon JE;Kutch JJ
人类运动皮层可以激活骨盆底肌肉（PFM），但运动皮层代表的PFM没有得到很好的表征。PFM代表被认为是集中在补充运动区（SMA）。在这里，我们研究的程度PFM表示之间的SMA和初级运动皮层（M1）分布，以及如何利用这种表示激活PFM在不同的协调模式。我们发现，两种类型的协调模式，涉及PFM可以自愿访问：一个激活PFM独立的增效剂和第二个激活PFM之前，并与增效剂的比例（在这项研究中，臀大肌- GMM）。功能性磁共振成像（fMRI）显示，这两种协调模式都涉及SMA和M1的重叠激活，这表明存在混合但独立的神经种群，它们可以访问不同的模式。经颅磁刺激（TMS）证实SMA和M1代表PFM。TMS还显示，同样对于SMA和M1，PFM可以在休息期间被激活，但GMM只能在自愿驱动到GMM后被激活，这表明这些人群通过激活阈值来区分。我们的结论是，PFM代表广泛分布在SMA和M1在人类。
Human motor cortex can activate pelvic floor muscles (PFM), but the motor cortical representation of the PFM is not well characterized. PFM representation is thought to be focused in the supplementary motor area (SMA). Here we examine the degree to which PFM representation is distributed between SMA and the primary motor cortex (M1), and how this representation is utilized to activate the PFM in different coordination patterns. We show that two types of coordination patterns involving PFM can be voluntarily accessed: one activates PFM independently of synergists and a second activates PFM prior to and in proportion with synergists (in this study, the gluteus maximus muscle – GMM). Functional magnetic resonance imaging (fMRI) showed that both coordination patterns involve overlapping activation in SMA and M1, suggesting the presence of intermingled but independent neural populations that access the different patterns. Transcranial magnetic stimulation (TMS) confirmed SMA and M1 representation for the PFM. TMS also showed that, equally for SMA and M1, PFM can be activated during rest but GMM can only be activated after voluntary drive to GMM, suggesting that these populations are distinguished by activation threshold. We conclude that PFM representation is broadly distributed in SMA and M1 in humans.
登录
查看更多内容
影响因子：
2.5
作者：
Bharat, R;Kavia, C;Fowler, CJ
通讯作者：
Fowler, CJ
影响因子：
5.3
作者：
Asavasopon, Skulpan;Rana, Manku;Kutch, Jason J.
通讯作者：
Kutch, Jason J.
影响因子：
15.9
作者：
GAHERY, Y;MASSION, J
通讯作者：
MASSION, J
影响因子：
2
作者：
Hetrick, DC;Glazer, H;Berger, RE
通讯作者：
Berger, RE
影响因子：
6.6
作者：
Kilpatrick, Lisa A.;Kutch, Jason J.;Tillisch, Kirsten;Naliboff, Bruce D.;Labus, Jennifer S.;Jiang, Zhiguo;Farmer, Melissa A.;Apkarian, A. Vania;Mackey, Sean;Martucci, Katherine T.;Clauw, Daniel J.;Harris, Richard E.;Deutsch, Georg;Ness, Timothy J.;Yang, Claire C.;Maravilla, Kenneth;Mullins, Chris;Mayer, Emeran A.
通讯作者：
Mayer, Emeran A.