Ensemble neural activity of the frontal cortical basal ganglia system predicts reaction time task performance in rats.
Ensemble neural activity of the frontal cortical basal ganglia system predicts reaction time task performance in rats.
复制标题
额叶皮质基底神经节系统的整体神经活动预测大鼠反应时任务表现
DOI：
10.1016/j.neures.2011.06.010
复制
发表时间：
2011-10
影响因子：
2.9
通讯作者：
Chang J
中科院分区：
文献类型：
--
作者：
Li X;Luo F;Shi L;Woodward DJ;Chang J
本研究追求的问题是皮质基底神经节系统中何时出现神经活动，可以预测反应时间（RT）任务中的替代行为反应。在此协议中，大鼠首先进行鼻子戳来启动试验，在出现时按下杠杆，然后在音调提示后释放杠杆。在一次训练中，从一只大鼠的前额皮质、背内侧纹状体、苍白球和黑质网状部同时获得多通道、单单元记录（最多 62 个单元）。结果表明：（1）神经活动的整体改变出现在簇中，这与不同的行为成分相关，并在每个目标区域中观察到； (2) 在这些行为发作期间，小的独立神经元子集在错误试验（在音调呈现之前释放杠杆）和正确试验（在音调出现后 0.5 秒内释放杠杆）之间的反应不同； (3)在任务的早期准备阶段发现RT和单单元活动之间存在显着相关性。结果表明，复杂的早期准备活动存在于 RT 任务的最终动作之前几秒钟，这可能决定导致快速解码替代行为表现的执行功能。
The question pursued in this study was when neural activity appears in the cortico-basal ganglia system that could predict alternate behavioral responses in a reaction time (RT) task. In this protocol, rats first performed a nose poke to initiate a trial, depressed a lever when presented, and then released the lever after a tone cue. Multiple-channel, single-unit recordings (up to 62 units) were obtained simultaneously from the prefrontal cortex, the dorsal medial striatum, the globus pallidus, and the substantia nigra pars reticulata in a single rat during a session. Results indicated that (1) global alterations of neural activity appeared in clusters, which was associated with different behavioral components and observed in each of the targeted areas; (2) small independent subsets of neurons responded differently between error (lever was released before tone presentation) and correct trials (lever was released within 0.5 s after tone onset) during these behavioral episodes; (3) significant correlations between RTs and single units activities were found in the early preparation phases of the task. The results reveal that complex early preparatory activity exists several seconds before the final movements in a RT task, which may determine executive functions leading to rapid decoding of alternate behavioral performances.
登录
查看更多内容
影响因子：
3.4
作者：
Baunez, C;Amalric, M
通讯作者：
Amalric, M
影响因子：
3.4
作者：
Christakou, A;Robbins, TW;Everitt, BJ
通讯作者：
Everitt, BJ
影响因子：
3.3
作者：
Chang, JY;Janak, PH;Woodward, DJ
通讯作者：
Woodward, DJ
影响因子：
3.8
作者：
Brasted, PJ;Döbrössy, MD;Dunnett, SB
通讯作者：
Dunnett, SB
影响因子：
3.4
作者：
AMALRIC, M;MOUKHLES, H;DASZUTA, A
通讯作者：
DASZUTA, A