Effects of sporadic transthyretin amyloidosis frequently on the gallbladder and the correlation between amyloid deposition in the gallbladder and heart: A forensic autopsy‐based histopathological evaluation
Effects of sporadic transthyretin amyloidosis frequently on the gallbladder and the correlation between amyloid deposition in the gallbladder and heart: A forensic autopsy‐based histopathological evaluation
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散发性运甲状腺素蛋白淀粉样变性频繁对胆囊的影响以及胆囊和心脏淀粉样蛋白沉积之间的相关性：基于法医尸检的组织病理学评估
DOI：
10.1111/pin.13127
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发表时间：
2021
影响因子：
2.2
通讯作者：
Nishida Naoki
中科院分区：
文献类型：
--
作者：
Ichimata Shojiro;Hata Yukiko;Nishida Naoki
本研究的目的是评估心脏受累患者胆囊ATTR沉积的临床病理特征，研究胆囊和心脏淀粉样蛋白沉积严重程度的相关性，并比较其在胆囊和其他器官中的患病率。确定了50例散发性ATTR淀粉样变性患者。其中，我们评估了15例准确进行胆囊取样的患者。在10例胆囊沉积患者（67%）中，6例在苏木精和伊红染色标本中显示可检测到沉积，所有患者均显示阻塞性血管沉积（VD）。胆囊VD的严重程度与心脏VD和心房间质沉积（ID）的严重程度相关。此外，所有表现出胆囊ID的患者都表现出严重的心室和心房ID。在除心脏外的内脏器官中，淀粉样蛋白沉积通常见于肺（93%），其次是胃肠道（47%-80%）、肝脏（60%）和骨膜组织（53%）。胆囊受累普遍，与胃肠道受累相似。此外，胆囊沉积的严重程度与心脏沉积的严重程度相关。因此，病理学家应该意识到散发性ATTR淀粉样变性是一种常见的疾病，不应被忽视。
The aim of the study is to evaluate the clinicopathological features of cholecystic ATTR deposition in patients with cardiac involvement, investigate the correlation of amyloid deposition severity in the gallbladder and the heart, and compare its prevalence in the gallbladder and other organs. Fifty patients with sporadic ATTR amyloidosis were identified. Of these, we evaluated 15 patients who underwent gallbladder sampling accurately. Among 10 patients (67%) with cholecystic deposition, six exhibited detectable deposition in the hematoxylin and eosin‐stained specimens, and all of them displayed obstructive vascular deposition (VD). The severity of gall bladder VD was statistically correlated with that of cardiac VD and atrial interstitial deposition (ID). Additionally, all patients exhibiting cholecystic ID displayed severe ventricular and atrial IDs. In visceral organs excluding the heart, amyloid deposition was commonly observed in the lungs (93%), followed by the gastrointestinal tract (47%‒80%), liver (60%) and periosteal tissues (53%). The involvement of the gallbladder was prevalent and comparable to that of the gastrointestinal tract. Moreover, the severity of cholecystic deposition was correlated with that of cardiac deposition. Therefore, pathologists should be aware that sporadic ATTR amyloidosis is a common condition and should not be overlooked.
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影响因子：
5.5
作者：
Falk, Rodney H.
通讯作者：
Falk, Rodney H.
影响因子：
2.1
作者：
Bray, F.;Balcaen, T.;Chazard, E.
通讯作者：
Chazard, E.
DOI：
--
发表时间：
2007
期刊：
J Gastroenterol 42
影响因子：
--
作者：
Kwon AH;Tsuji K;Yamada H;Okazaki K;Sakaida N.
通讯作者：
Sakaida N.
淀粉样变性表现为慢性胆囊炎误诊风湿性多肌痛一例。
影响因子：
--
作者：
Y. Um;Hyoun;Jin;Hundo Cho;J. Kang
通讯作者：
J. Kang
DOI：
10.3109/13506129.2015.1115758
发表时间：
2016-01
期刊：
Amyloid
影响因子：
--
作者：
Akihiro Yanagisawa;M. Ueda;Takanao Sueyoshi;E. Nakamura;M. Tasaki;G. Suenaga;Hiroaki Motokawa;Risa Toyoshima;Y. Kinoshita;Y. Misumi;T. Yamashita;M. Sakaguchi;P. Westermark;H. Mizuta;Y. Ando
通讯作者：
Akihiro Yanagisawa;M. Ueda;Takanao Sueyoshi;E. Nakamura;M. Tasaki;G. Suenaga;Hiroaki Motokawa;Risa Toyoshima;Y. Kinoshita;Y. Misumi;T. Yamashita;M. Sakaguchi;P. Westermark;H. Mizuta;Y. Ando