Cerebrovascular reactivity among native-raised high altitude residents: an fMRI study.
Cerebrovascular reactivity among native-raised high altitude residents: an fMRI study.
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土生土长的高海拔居民的脑血管反应性：一项功能磁共振成像研究
DOI：
10.1186/1471-2202-12-94
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发表时间：
2011-09-26
期刊：
影响因子：
2.4
通讯作者：
Weng X
中科院分区：
文献类型：
--
作者：
Yan X;Zhang J;Gong Q;Weng X
研究背景近年来，长期居住在高海拔地区（HA）对人脑的影响引起了研究者的关注。本研究调查了本地出生的高海拔（HA）居民的脑血管反应性相比，本地海平面（SL）居民。这两组人在祖先血统、年龄、性别比例和教育水平上都是匹配的。视觉提示引导最大的吸气任务与短暂的屏气进行了所有的科目，而血氧水平依赖（BOLD）功能磁共振成像（fMRI）的数据从them.ResultsCompared SL控制，HA组表现出普遍降低脑血管反应性和血流动力学反应的延迟时间较长。在前一个方面差异显著的簇位于双侧初级运动皮层、右侧躯体感觉联合皮层、右侧丘脑和右侧尾状核、双侧楔前叶、右侧扣带回和右侧后扣带回、左侧梭状回和右侧舌皮层;在后一个方面显示出显著差异的簇位于楔前叶、枕叶、上级额颞回、躯体感觉皮层（中央后回）和小脑扁桃体。吸气储备量（IRV），这是一个重要的方面，肺功能，表现出显着的相关性，BOLD信号的变化量在多个脑区，特别是在HA group.ConclusionsNative-born HA居民普遍表现出降低脑血管反应的血流动力学反应在视觉提示引导的最大吸气任务进行BOLD-fMRI。这种效应在通常参与呼吸的大脑调节的大脑区域中特别明显。
BackgroundThe impact of long term residence on high altitude (HA) on human brain has raised concern among researchers in recent years. This study investigated the cerebrovascular reactivity among native-born high altitude (HA) residents as compared to native sea level (SL) residents. The two groups were matched on the ancestral line, ages, gender ratios, and education levels. A visual cue guided maximum inspiration task with brief breath holding was performed by all the subjects while Blood-Oxygenation-Level-Dependent (BOLD) functional Magnetic Resonance Imaging (fMRI) data were acquired from them.ResultsCompared to SL controls, the HA group showed generally decreased cerebrovascular reactivity and longer delay in hemodynamic response. Clusters showing significant differences in the former aspect were located at the bilateral primary motor cortex, the right somatosensory association cortex, the right thalamus and the right caudate, the bilateral precuneus, the right cingulate gyrus and the right posterior cingulate cortex, as well as the left fusiform gyrus and the right lingual cortex; clusters showing significant differences in the latter aspect were located at the precuneus, the insula, the superior frontal and temporal gyrus, the somatosensory cortex (the postcentral gyrus) and the cerebellar tonsil. Inspiratory reserve volume (IRV), which is an important aspect of pulmonary function, demonstrated significant correlation with the amount of BOLD signal change in multiple brain regions, particularly at the bilateral insula among the HA group.ConclusionsNative-born HA residents generally showed reduced cerebrovascular reactivity as demonstrated in the hemodynamic response during a visual cue guided maximum inspiration task conducted with BOLD-fMRI. This effect was particularly manifested among brain regions that are typically involved in cerebral modulation of respiration.
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3.3
作者：
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