Mechanisms of microRNA-mediated gene regulation in unicellular model alga Chlamydomonas reinhardtii.

Mechanisms of microRNA-mediated gene regulation in unicellular model alga Chlamydomonas reinhardtii.
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单细胞模型藻类莱茵衣藻 microRNA 介导的基因调控机制

DOI:
10.1186/s13068-018-1249-y
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发表时间:
2018
影响因子:
6.3
通讯作者:
Hu Z
Hu Z
中科院分区:
工程技术1区
文献类型:
--
作者:
Lou S;Sun T;Li H;Hu Z

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MicroRNAs是一类内源性非编码rna,在真核细胞的转录后基因调控中起着重要作用。在植物和动物中,mirna涉及多种角色,包括免疫病毒感染、发育途径、癌症分子病理和蛋白质表达调节。然而,mirna在单细胞模型绿藻莱茵单胞藻中的作用尚不清楚。mirna诱导的基因沉默在激活rna诱导的沉默复合体和靶向mRNA方面的作用方式与高等真核生物非常相似。一些研究表明,mRNA的不稳定和mRNA的转换可能是真核藻类中mirna的主要功能。在这里,我们总结了最近的发现,这些发现提高了我们对miRNA调控机制的理解。
MicroRNAs are a class of endogenous non-coding RNAs that play a vital role in post-transcriptional gene regulation in eukaryotic cells. In plants and animals, miRNAs are implicated in diverse roles ranging from immunity against viral infections, developmental pathways, molecular pathology of cancer and regulation of protein expression. However, the role of miRNAs in the unicellular model green algaChlamydomonas reinhardtiiremains unclear. The mode of action of miRNA-induced gene silencing inC. reinhardtiiis very similar to that of higher eukaryotes, in terms of the activation of the RNA-induced silencing complex and mRNA targeting. Certain studies indicate that destabilization of mRNAs and mRNA turnover could be the major possible functions of miRNAs in eukaryotic algae. Here, we summarize recent findings that have advanced our understanding of miRNA regulatory mechanisms inC. reinhardtii.
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