Tumor suppressor gene methylation in follicular lymphoma: a comprehensive review.
Tumor suppressor gene methylation in follicular lymphoma: a comprehensive review.
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DOI：
10.1186/1476-4598-5-44
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发表时间：
2006-10-06
期刊：
影响因子：
37.3
通讯作者：
Montero A
中科院分区：
文献类型：
--
作者：
Hayslip J;Montero A
与DNA甲基化相关的肿瘤抑制基因的转录沉默是恶性血液病中常见的表观遗传事件。虽然CpG岛的DNA超甲基化在急性白血病和骨髓增生异常综合征中有很好的描述，但对滤泡性B细胞淋巴瘤中常见的特异性甲基化变化知之甚少。滤泡性淋巴瘤的早期甲基化研究仅涉及细胞系;然而，越来越多的文献报道了原发性人类FL样本中的甲基化变化。已发表的原发性滤泡性淋巴瘤标本研究表明：雄激素受体、SHP 1和死亡相关蛋白激酶基因通常是甲基化的。相比之下，细胞周期蛋白依赖性激酶抑制剂p15，p16和p57是滤泡性淋巴瘤中不常见的表观遗传事件。细胞周期蛋白依赖性激酶抑制剂甲基化在高级别淋巴瘤中更为常见，可能是滤泡性淋巴瘤进展和转化的重要步骤。滤泡性淋巴瘤的进一步甲基化研究应该调查这些表观遗传学变化的预后和治疗意义，并调查其他基因的甲基化。最后，通过使用低甲基化剂重新激活甲基化的肿瘤抑制基因是治疗惰性和转化的滤泡性淋巴瘤的一种有前途的新方法。
Transcriptional silencing of tumor suppressor genes, associated with DNA methylation, is a common epigenetic event in hematologic malignancies. Although DNA hypermethylation of CpG islands is well described in acute leukemias and myelodysplastic syndromes, much less is known of the specific methylation changes that commonly occur in follicular B cell lymphomas. Earlier methylation studies of follicular lymphoma involved only cell lines; however there is a growing literature of methylation changes in primary human FL samples. Published studies of primary follicular lymphoma specimens have demonstrated that: androgen receptor, SHP1, and death-associated protein kinase genes are commonly methylated. By contrast, the cyclin dependent kinase inhibitors p15, p16, and p57 are uncommon epigenetic events in follicular lymphoma. Methylation of cyclin dependent kinase inhibitors is more common in high grade lymphomas, and may be an important step in the progression and transformation of follicular lymphoma. Further methylation studies in follicular lymphoma should investigate the prognostic and therapeutic significance of these epigenetic changes and investigate methylation of other genes. Finally, reactivation of methylated tumor suppressor genes through the use of hypomethylating agents is a promising and novel approach to the treatment of indolent and transformed follicular lymphomas.
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影响因子：
4.4
作者：
Ellis, TM;Moser, MT;Kwon, ED
通讯作者：
Kwon, ED
DOI：
10.1017/s0016672306008184
发表时间：
2006-06-01
期刊：
GENETICAL RESEARCH
影响因子：
--
作者：
Iida, Atsuo;Shimada, Atsuko;Koga, Akihiko
通讯作者：
Koga, Akihiko
影响因子：
37.3
作者：
Hayslip J;Montero A
通讯作者：
Montero A
影响因子：
32.4
作者：
CYSTER, JG;GOODNOW, CC
通讯作者：
GOODNOW, CC
影响因子：
10.5
作者：
DEISS, LP;FEINSTEIN, E;KIMCHI, A
通讯作者：
KIMCHI, A