A Lindenmayer system-based approach for the design of nutrient delivery networks in tissue constructs
A Lindenmayer system-based approach for the design of nutrient delivery networks in tissue constructs
复制标题
基于 Lindenmayer 系统的组织构建中营养输送网络设计方法
DOI：
10.1088/1758-5082/1/4/045004
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发表时间：
2009
期刊：
影响因子：
9
通讯作者：
B. Starly
中科院分区：
文献类型：
--
作者：
O. Yasar;Shih;B. Starly
据报道，大型厚组织结构的成功有限，主要是由于细胞无法在支架内部存活。如果不能获得足够的营养，放置在组织结构深处的细胞就会死亡，导致组织再生不均匀。目前，有必要在组织结构中设计营养管道网络，使细胞能够在基质中存活。然而，在组织结构中设计复杂的网络是具有挑战性的。在本文中，我们提出了Lindenmayer系统，一个优雅的基于分形的语言算法框架，以生成具有不同程度复杂性的二维和三维结构的管道网络。导管网络在网络的每个分支之间保持父子关系。研究了几个l -系统参数——分支角、分支长度、父分支与子分支直径的比值等，以模拟给定l -系统符号下的几种体系结构。我们还提出了一种基于分层制造的紫外光聚合工艺，使用德州仪器DLP™系统来制造分支结构。这项初步工作展示了基于l系统的结构设计在驱动脚手架制造系统中的适用性。
Large thick tissue constructs have reported limited success primarily due to the inability of cells to survive deep within the scaffold. Without access to adequate nutrients, cells placed deep within the tissue construct will die out, leading to non-uniform tissue regeneration. Currently, there is a necessity to design nutrient conduit networks within the tissue construct to enable cells to survive in the matrix. However, the design of complex networks within a tissue construct is challenging. In this paper, we present the Lindenmayer system, an elegant fractal-based language algorithm framework, to generate conduit networks in two- and three-dimensional architecture with several degrees of complexity. The conduit network maintains a parent–child relationship between each branch of the network. Several L-system parameters have been studied—branching angle, branch length, ratio of parent to child branch diameter, etc—to simulate several architectures under a given L-system notation. We have also presented a layered manufacturing-based UV-photopolymerization process using the Texas Instruments DLP™ system to fabricate the branched structures. This preliminary work showcases the applicability of L-system-based construct designs to drive scaffold fabrication systems.
影响因子：
56.9
作者：
Chen, CS;Mrksich, M;Ingber, DE
通讯作者：
Ingber, DE
影响因子：
--
作者：
Freed, Lisa E.;Guilak, Farshid;Vunjak-Novakovic, Gordana
通讯作者：
Vunjak-Novakovic, Gordana
影响因子：
56.9
作者：
Niklason, LE;Gao, J;Langer, R
通讯作者：
Langer, R