Salicylate-induced auditory perceptual disorders and plastic changes in nonclassical auditory centers in rats.
Salicylate-induced auditory perceptual disorders and plastic changes in nonclassical auditory centers in rats.
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DOI：
10.1155/2014/658741
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发表时间：
2014
影响因子：
3.1
通讯作者：
Salvi R
中科院分区：
文献类型：
--
作者：
Chen GD;Radziwon KE;Kashanian N;Manohar S;Salvi R
先前的研究表明，水杨酸钠（SS）不仅激活中枢听觉结构，而且激活与情绪和记忆相关的非听觉区域。为了确定非听觉区域的电生理变化，我们记录了ss治疗后纹状体、杏仁核、海马和扣带回皮层的声诱发局部场电位和多单元放电。ss治疗产生了耳鸣和听觉亢进的行为证据。从生理上讲，该疗法显著增强了纹状体、杏仁核和海马体中声音诱发的神经活动，但没有增强扣带回。增强的声音诱发反应可能与超听觉样行为有关。进一步的分析表明，声音诱发活动的增强主要发生在中频，这可能反映了我们之前在听觉皮层和杏仁核的研究中观察到的ss治疗后神经元向中频范围的转移。中频神经元数量的增加会导致中频区域的总自发放电数量相对增加，尽管每个神经元的平均放电率可能不会增加。安静时中频区域的张力局部过度活动可能潜在地导致中频音调感觉（耳鸣）。杏仁核和海马体的神经变化也可能有助于患者与耳鸣相关的负面影响。
Previous studies have shown that sodium salicylate (SS) activates not only central auditory structures, but also nonauditory regions associated with emotion and memory. To identify electrophysiological changes in the nonauditory regions, we recorded sound-evoked local field potentials and multiunit discharges from the striatum, amygdala, hippocampus, and cingulate cortex after SS-treatment. The SS-treatment produced behavioral evidence of tinnitus and hyperacusis. Physiologically, the treatment significantly enhanced sound-evoked neural activity in the striatum, amygdala, and hippocampus, but not in the cingulate. The enhanced sound evoked response could be linked to the hyperacusis-like behavior. Further analysis showed that the enhancement of sound-evoked activity occurred predominantly at the midfrequencies, likely reflecting shifts of neurons towards the midfrequency range after SS-treatment as observed in our previous studies in the auditory cortex and amygdala. The increased number of midfrequency neurons would lead to a relative higher number of total spontaneous discharges in the midfrequency region, even though the mean discharge rate of each neuron may not increase. The tonotopical overactivity in the midfrequency region in quiet may potentially lead to tonal sensation of midfrequency (the tinnitus). The neural changes in the amygdala and hippocampus may also contribute to the negative effect that patients associate with their tinnitus.
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影响因子：
5.3
作者：
CAMPEAU, S;DAVIS, M
通讯作者：
DAVIS, M
影响因子：
1.9
作者：
BORDI, F;LEDOUX, J;PAVLIDES, C
通讯作者：
PAVLIDES, C
影响因子：
2.8
作者：
Brozoski, TJ;Bauer, CA
通讯作者：
Bauer, CA
影响因子：
3.3
作者：
Cheung, S. W.;Larson, P. S.
通讯作者：
Larson, P. S.
DOI：
10.1080/01688638508401242
发表时间：
1985-01-01
影响因子：
2.2
作者：
ARAM, DM;EKELMAN, BL;WHITAKER, HA
通讯作者：
WHITAKER, HA