Neighborhood deprivation and risk of cancer incidence, mortality and survival: results from a population-based cohort study in Japan.

Neighborhood deprivation and risk of cancer incidence, mortality and survival: results from a population-based cohort study in Japan.
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DOI:
10.1371/journal.pone.0106729
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发表时间:
2014
期刊:
影响因子:
3.7
通讯作者:
JPHC Study Group
JPHC Study Group
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Miki Y;Inoue M;Ikeda A;Sawada N;Nakaya T;Shimazu T;Iwasaki M;Yamaji T;Sasazuki S;Shibuya K;Tsugane S;JPHC Study Group

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在许多发达国家,社会经济地位与癌症发病率和存活率有关。然而,日本的研究很少。在基于日本公共卫生中心的前瞻性研究中,我们研究了基于日本剥夺指数的社区剥夺与总癌症和主要癌症的发病率、死亡率和存活率之间的关系。对86,112名参与者进行了跟踪调查,直至2009年底。在1,348,437人年的跟踪(平均跟踪:15.7年)中,共发现10,416例病例和5,510例癌症死亡。日本人的剥夺指数被用来评估邻居的剥夺。用COX回归分析计算危险比和95%可信区间。我们发现,邻里剥夺指数与总癌症和主要癌症的发病率之间没有关联。然而,在一些癌症风险或死亡中,我们发现与较高的剥夺指数正或负相关,例如女性结直肠癌发病率的降低和肝癌发病率和死亡风险的增加。尽管在特定地点检测到了一些正相关或负相关,但在日本人口中,邻里剥夺指数与癌症的发病率、死亡率和存活率没有实质性的总体关联。
In many developed countries, socioeconomic status is associated with cancer incidence and survival. However, research in Japan is sparse. We examined the association between neighborhood deprivation based on the Japanese Deprivation Index and the risk of incidence, mortality and survival from total and major cancers in the Japan Public Health Center-based Prospective Study. 86,112 participants were followed through the end of 2009. A total of 10,416 incident cases and 5,510 deaths from cancer were identified among 1,348,437 person-years of follow-up (mean follow-up: 15.7 years). The Japanese deprivation index was used to access neighborhood deprivation. Hazard ratios and 95% confidence intervals were calculated by Cox regression analysis. We found no associations between neighborhood deprivation index and the incidence of total and major cancers. In some cancer risks or deaths, however, we found positive or inverse associations with a higher deprivation index, such as a decreased risk of colorectal cancer incidence and an increased risk of liver cancer incidence and deaths in women. Although some positive or inverse associations were detected for specific sites, the neighborhood deprivation index has no substantial overall association with the risk of incidence, mortality and survival from cancer in the Japanese population.
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