Relation between Cerebral Blood Flow and Metabolism Explained by a Model of Oxygen Exchange
Relation between Cerebral Blood Flow and Metabolism Explained by a Model of Oxygen Exchange
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氧交换模型解释脑血流量与代谢之间的关系
DOI：
10.1097/01.wcb.0000055178.31872.38
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发表时间：
2003
影响因子：
6.3
通讯作者：
R. Costalat
中科院分区：
文献类型：
--
作者：
R. Valabrègue;Agnès Aubert;J. Burger;J. Bittoun;R. Costalat
脑血流量（CBF）和脑氧代谢率（CMRO2）是功能磁共振成像和光学成像对比度的主要决定因素。然而，CBF 和 CMRO2 在大脑激活过程中的耦合仍然存在争议。尽管大多数先前的模型都倾向于表现出非线性耦合，但实验研究却得出了相互矛盾的结论。开发了动态和静态状态下氧通过血脑屏障（BBB）运输的生理模型。提出了常见的模型简化，并研究了它们对 CBF/CMRO2 关系的影响。组织氧池、BBB 通透性和血红蛋白解离曲线是直接涉及 CBF/CMRO2 关系的生理参数。我们已经证明，大多数先前模型都承认组织氧池可忽略不计的假设意味着 CBF 和 CMRO2 之间的紧密耦合。通过放宽这一假设，允许真正的解耦，从而给出 CBF/CMRO2 关系的更连贯的视图，与高碳酸血症数据以及实验工作中报告的这两个变量相对变化的变异性更好地一致。这也使得 CBF 和 CMRO2 之间存在时间不匹配，从而影响毛细血管末端氧合的时间形状。
The cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO2) are major determinants of the contrast in functional magnetic resonance imaging and optical imaging. However, the coupling between CBF and CMRO2 during cerebral activation remains controversial. Whereas most of the previous models tend to show a nonlinear coupling, experimental studies have led to conflicting conclusions. A physiologic model was developed of oxygen transport through the blood–brain barrier (BBB) for dynamic and stationary states. Common model simplifications are proposed and their implications for the CBF/CMRO2 relation are studied. The tissue oxygen pool, the BBB permeability, and the hemoglobin dissociation curve are physiologic parameters directly involved in the CBF/CMRO2 relation. We have been shown that the hypothesis of a negligible tissue oxygen pool, which was admitted by most of the previous models, implies a tight coupling between CBF and CMRO2. By relaxing this hypothesis, a real uncoupling was allowed that gives a more coherent view of the CBF/CMRO2 relation, in better agreement with the hypercapnia data and with the variability reported in experimental works for the relative changes of those two variables. This also allows a temporal mismatch between CBF and CMRO2, which influences the temporal shape of oxygenation at the capillary end.
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通过三维微血管网络向肿瘤输送氧气的理论模拟。
影响因子：
--
作者：
Secomb,TW;Hsu,R;Braun,RD;Ross,JR;Gross,JF;Dewhirst,MW
通讯作者：
Dewhirst,MW
DOI：
10.1073/pnas.83.4.1140
发表时间：
1986-02-01
影响因子：
11.1
作者：
FOX, PT;RAICHLE, ME
通讯作者：
RAICHLE, ME
影响因子：
3.4
作者：
CLARK, A;FEDERSPIEL, WJ;COKELET, GR
通讯作者：
COKELET, GR
影响因子：
2
作者：
Goldman, D;Popel, AS
通讯作者：
Popel, AS
影响因子：
3.3
作者：
Hyder, F;Shulman, RG;Rothman, DL
通讯作者：
Rothman, DL