Evolutionary relationships of wild hominids recapitulated by gut microbial communities.
Evolutionary relationships of wild hominids recapitulated by gut microbial communities.
复制标题
DOI：
10.1371/journal.pbio.1000546
复制
发表时间：
2010-11-16
期刊：
影响因子：
9.8
通讯作者：
Hugenholtz P
中科院分区：
文献类型：
--
作者：
Ochman H;Worobey M;Kuo CH;Ndjango JB;Peeters M;Hahn BH;Hugenholtz P
虽然细菌在个体的一生中不断获得，但类人猿物种的系统发育关系反映在其肠道微生物群落的组成中。个体一生中的多种因素，包括饮食、地理和生理状态，都会影响灵长类动物肠道内的微生物群落。为了确定物种内和物种间微生物群组成的变化来源，我们调查了大猩猩所携带的远端肠道微生物群落，如在其原生范围内回收的粪便样品中所示。我们发现，这些微生物群落的组成的基础上的宿主种的分支顺序是完全一致的主机的已知关系。尽管肠道最初并持续地接种了从外部来源获得的细菌，但我们确定，在进化时间尺度上，类人猿物种的肠道微生物群组成在系统发育上是保守的，并且以与垂直遗传一致的方式发生了分化。栖息在人类和其他哺乳动物胃肠道的微生物群落是复杂的，动态的，对健康和疾病都至关重要。这些群落的组成和成分受到多种因素的影响，如宿主的饮食，地理，生理和疾病状态。鉴于肠道微生物群在宿主生理学中的核心作用，重要的是确定它是可预测的并且基本上由宿主决定，还是可变的并且主要由宿主经历的外部环境（包括饮食）决定。确定这些因素的相对贡献的一个有价值的方法是通过比较密切相关的宿主物种的肠道微生物群落。应用高通量测序方法，我们对在其原生范围内采样的巨猿物种的远端肠道微生物进行了分析，然后对遗传信息丰富的肠道微生物类型（即，存在于多个个体中的细菌分类群）以确定不同微生物群落之间的关系。我们的分析揭示了微生物群落结构的明确物种特异性特征。此外，五种大型类人猿（智人、黑猩猩、Paniscus、大猩猩和G. beringei）与从宿主线粒体DNA推断的结果相同，表明宿主的生殖过程在进化时间尺度上塑造了肠道微生物群。看来你毕竟不是你吃的东西。
Although bacteria are continually acquired over the lifetime of an individual, the phylogenetic relationships of great ape species is mirrored in the compositions of their gut microbial communities. Multiple factors over the lifetime of an individual, including diet, geography, and physiologic state, will influence the microbial communities within the primate gut. To determine the source of variation in the composition of the microbiota within and among species, we investigated the distal gut microbial communities harbored by great apes, as present in fecal samples recovered within their native ranges. We found that the branching order of host-species phylogenies based on the composition of these microbial communities is completely congruent with the known relationships of the hosts. Although the gut is initially and continuously seeded by bacteria that are acquired from external sources, we establish that over evolutionary timescales, the composition of the gut microbiota among great ape species is phylogenetically conserved and has diverged in a manner consistent with vertical inheritance. The microbial communities that inhabit the gastrointestinal tract of humans and other mammals are complex, dynamic, and critical to both health and disease. The composition and constituents of these communities are influenced by multiple factors such as host diet, geography, physiology, and disease state. Given the central role of the gut microbiota in the physiology of the host, it is important to determine whether it is predictable and substantially determined by the host, or variable and largely determined by the external environment (including diet) experienced by the host. A valuable way of determining the relative contributions of such factors is by comparing gut microbial communities in closely related host species. Applying a high-throughput sequencing approach, we profiled the distal gut microbiotae of great ape species sampled in their native ranges and then employed a parsimony-based analysis of phylogenetically informative phylotypes (i.e., bacterial taxa residing in multiple individuals) to determine the relationships among the diverse microbial communities. Our analyses revealed a clear species-specific signature of microbial community structure. Moreover, the pattern of relationships among the five great ape species (Homo sapiens, Pan troglodytes, P. paniscus, Gorilla gorilla, and G. beringei) inferred from their fecal microbial communities was identical to that inferred from host mitochondrial DNA, indicating that host phylogeny shapes the gut microbiota over evolutionary timescales. It seems after all that you are not what you eat.
登录
查看更多内容
影响因子：
64.8
作者：
Keele, Brandon F.;Jones, James Holland;Terio, Karen A.;Estes, Jacob D.;Rudicell, Rebecca S.;Wilson, Michael L.;Li, Yingying;Learn, Gerald H.;Beasley, T. Mark;Schumacher-Stankey, Joann;Wroblewski, Emily;Mosser, Anna;Raphael, Jane;Kamenya, Shadrack;Lonsdorf, Elizabeth V.;Travis, Dominic A.;Mlengeya, Titus;Kinsel, Michael J.;Else, James G.;Silvestri, Guido;Goodall, Jane;Sharp, Paul M.;Shaw, George M.;Pusey, Anne E.;Hahn, Beatrice H.
通讯作者：
Hahn, Beatrice H.
高度平行的焦索测序者产生的16S rRNA序列的准确分类学分配。
影响因子：
14.9
作者：
Liu Z;DeSantis TZ;Andersen GL;Knight R
通讯作者：
Knight R
影响因子：
12.3
作者：
Huse SM;Huber JA;Morrison HG;Sogin ML;Welch DM
通讯作者：
Welch DM
影响因子：
11
作者：
Auguet, Jean-Christophe;Barberan, Albert;Casamayor, Emilio O.
通讯作者：
Casamayor, Emilio O.
影响因子：
4.4
作者：
Lauber, Christian L.;Hamady, Micah;Fierer, Noah
通讯作者：
Fierer, Noah