Human exposure to particulate matter potentially contaminated with sin nombre virus.
Human exposure to particulate matter potentially contaminated with sin nombre virus.
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DOI：
10.1007/s10393-013-0830-x
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发表时间：
2013-06
期刊：
影响因子：
2.5
通讯作者：
Carver, Scott
中科院分区：
文献类型：
--
作者：
Richardson, Kyle S.;Kuenzi, Amy;Douglass, Richard J.;Hart, Julie;Carver, Scott
关键词：
在整个北美，人类接触汉坦病毒的最常见机制是吸入被病毒污染的微粒。然而，与暴露于可能被汉坦病毒污染的颗粒有关的风险因素通常还没有得到很好的了解。在北美，Sin Nombre病毒（SNV）是感染人类的最常见汉坦病毒，引起汉坦病毒肺综合征，死亡率很高（约35%）。我们调查了人类对颗粒物的暴露情况，并评估了季节、地点（森林和住宅周围环境）和活动（步行和扫地）对呼吸区（离地面1.5 m）颗粒物产生的影响。我们发现，与秋季和冬季相比，春季和夏季产生的可吸入微粒量更大，而与森林环境相比，室内产生的可吸入微粒量更大。此外，与扫地相比，走路时呼吸区产生的颗粒量更大。结果表明，春季和夏季产生了更多的雾化颗粒。我们的研究结果表明，在春季和夏季，仅仅在建筑物内走动就是人类暴露于可能被SNV污染的颗粒物的重要来源。这些发现可以通过研究SNV最可能附着的颗粒大小以及人类在呼吸道的何处被感染来推进。
The most common mechanism for human exposure to hantaviruses throughout North America is inhalation of virally contaminated particulates. However, risk factors associated with exposure to particulates potentially contaminated with hantaviruses are generally not well understood. In North America, Sin Nombre virus (SNV) is the most common hantavirus that infects humans, causing hantavirus pulmonary syndrome, which has a significant mortality rate (approximately 35%). We investigated human exposure to particulate matter and evaluated the effects of season, location (sylvan and peridomestic environment), and activity (walking and sweeping) on generation of particulates at the breathing zone (1.5 m above the ground). We found greater volumes of small inhalable particulates during the spring and summer compared to the fall and winter seasons and greater volumes of small inhalable particulates produced in peridomestic, compared to sylvan, environments. Also, greater volumes of particulates were generated at the breathing zone while walking compared to sweeping. Results suggest that more aerosolized particles were generated during the spring and summer months. Our findings suggest that simply moving around in buildings is a significant source of human exposure to particulates, potentially contaminated with SNV, during spring and summer seasons. These findings could be advanced by investigation of what particle sizes SNV is most likely to attach to, and where in the respiratory tract humans become infected.
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影响因子：
11.8
作者：
Mills JN;Ksiazek TG;Peters CJ;Childs JE
通讯作者：
Childs JE
DOI：
10.4269/ajtmh.2001.65.33
发表时间：
2001-07-01
影响因子：
3.3
作者：
Douglass, RJ;Wilson, T;Mills, JN
通讯作者：
Mills, JN
影响因子：
3.5
作者：
Gedeon, Tomas;Bodelon, Clara;Kuenzi, Amy
通讯作者：
Kuenzi, Amy
DOI：
10.4269/ajtmh.1995.52.393
发表时间：
1995-05-01
影响因子：
3.3
作者：
CHILDS, JE;KREBS, JW;PETERS, CJ
通讯作者：
PETERS, CJ
影响因子：
11.8
作者：
Jay, M;Ascher, MS;Reilly, K
通讯作者：
Reilly, K