The unexplained female predominance of systemic lupus erythematosus: clues from genetic and cytokine studies.
The unexplained female predominance of systemic lupus erythematosus: clues from genetic and cytokine studies.
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DOI：
10.1007/s12016-009-8192-4
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发表时间：
2011-02
影响因子：
9.1
通讯作者：
Niewold, Timothy B.
中科院分区：
文献类型：
--
作者：
Weckerle, Corinna E.;Niewold, Timothy B.
尽管最近对系统性红斑狼疮（SLE）的了解有所进展，但令人震惊的9:1的男女发病率比例仍在很大程度上无法解释。此外，SLE的发病率高峰发生在女性的早期生育年龄。阐明这种性别差异和生殖年龄特征性发病的潜在原因的研究有可能从根本上促进我们对SLE疾病发病机制的理解。同样，这一领域的进展可能会为人类生殖免疫学提供信息。研究性激素在免疫系统中的功能具有明显的重要性；然而，似乎许多其他类型的与性别相关的遗传和免疫差异也可能导致SLE。在这篇综述中，我们将重点介绍细胞因子通路的性别相关差异以及这些通路的遗传学，因为它们与SLE发病机制有关。这些性别相关的差异似乎很可能对生殖健康很重要，这可能解释了这些免疫系统特征的保存和观察到的SLE女性优势。
Despite recent progress in the understanding of systemic lupus erythematosus (SLE), the striking 9:1 female to male ratio of disease incidence remains largely unexplained. In addition, peak SLE incidence rates occur during the early reproductive years in women. Studies which illuminate potential causes underlying this sex difference and characteristic onset during the reproductive years have the potential to fundamentally advance our understanding of disease pathogenesis in SLE. Similarly, progress in this area will likely inform human reproductive immunology. Studies of sex hormone function in the immune system are of obvious importance; however, it seems likely that many other types of sex-related genetic and immunological differences will contribute to SLE. In this review, we will focus on recent work in sex-related differences in cytokine pathways and genetics of these pathways as they relate to SLE pathogenesis. It seems quite possible that many of these sex-related differences could be important to reproductive fitness, which may explain the conservation of these immune system features and the observed female predominance of SLE.
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DOI：
10.1002/art.10248
发表时间：
2002-04-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Doria, A;Cutolo, M;Gambari, PF
通讯作者：
Gambari, PF
影响因子：
56.9
作者：
Blanco, P;Palucka, AK;Banchereau, J
通讯作者：
Banchereau, J
影响因子：
5
作者：
Cooney, C. M.;Bruner, G. R.;Aberle, T.;Namjou-Khales, B.;Myers, L. K.;Feo, L.;Li, S.;D'Souza, A.;Ramirez, A.;Harley, J. B.;Scofield, R. H.
通讯作者：
Scofield, R. H.
影响因子：
158.5
作者：
HOOKS, JJ;MOUTSOPOULOS, HM;NOTKINS, AL
通讯作者：
NOTKINS, AL
DOI：
10.1073/pnas.0901181106
发表时间：
2009-04-14
影响因子：
11.1
作者：
Jacob, Chaim O.;Zhu, Jiankun;Mohan, Chandra
通讯作者：
Mohan, Chandra