Predicting the mosquito species and vertebrate species involved in the theoretical transmission of Rift Valley fever virus in the United States.
Predicting the mosquito species and vertebrate species involved in the theoretical transmission of Rift Valley fever virus in the United States.
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DOI：
10.1371/journal.pntd.0003163
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发表时间：
2014-09
影响因子：
3.8
通讯作者：
Hamer GL
中科院分区：
文献类型：
--
作者：
Golnar AJ;Turell MJ;LaBeaud AD;Kading RC;Hamer GL
裂谷热病毒（RVFV）是布尼亚病毒科的一种蚊媒病毒，已在整个非洲大陆蔓延到马达加斯加和阿拉伯半岛。在北美建立裂谷热病毒除了对畜牧业产生重大经济影响外，还将对人类和动物健康产生严重后果。将来自美国的关于裂谷热病毒媒介能力、脊椎动物宿主能力和蚊子摄食模式的已发表和未发表的数据结合起来，定量地暗示蚊子媒介和脊椎动物宿主可能对裂谷热病毒在美国的传播很重要。基于已发表的蚊虫传播研究，利用病毒血症-媒介能力关系计算脊椎动物宿主能力指数，并结合蚊虫吸血模式近似计算媒介和脊椎动物的扩增分数，定义为蚊虫或脊椎动物宿主对病原体传播的相对贡献。结果表明，在美国，几种伊蚊、蚊子和偶蹄目脊椎动物是裂谷热病毒传播的重要宿主。本研究确定了知识上的关键空白，这些空白将有助于完成一项全面分析，确定蚊子和脊椎动物对美国潜在的裂谷热病毒传播的不同贡献。未来的研究应集中在(1)病毒暴露与关键蚊子物种的后续传染性之间的剂量依赖关系，(2)评估北美哺乳动物物种中脊椎动物宿主对裂谷热病毒的能力。(3)确定裂谷热病毒传入高风险地区，以便有关当地病媒和宿主种群的数据有助于产生适合地理位置的扩增分数估计。由于全球化、气候变化和其他因素，预计美国将继续出现病原体，因此，制定积极主动的管理计划和干预措施来预测和干预将比病原体出现后制定的回顾性计划更有效。裂谷热病毒等蚊媒病原体的有效管理需要了解不同蚊子种类和脊椎动物宿主在传播中所起的作用。本研究结合蚊虫传播效率、蚊虫取食模式和脊椎动物传染性等数据，定量评价了不同蚊子种类和脊椎动物宿主对美国裂谷热病毒扩增的相对重要性。我们确定了几种洪水伊蚊可能是裂谷热病毒最可能的传播媒介，有蹄动物（鹿、牛、羊）可能是最重要的扩增脊椎动物宿主。尽管这些数据为公共和动物卫生机构提供了关于媒介控制应针对的主要蚊子和最优先接种疫苗的动物的先验知识，但这一分析揭示了知识上的许多空白，降低了我们预测和随后管理裂谷热病毒潜在入侵的能力。
Rift Valley fever virus (RVFV) is a mosquito-borne virus in the family Bunyaviridiae that has spread throughout continental Africa to Madagascar and the Arabian Peninsula. The establishment of RVFV in North America would have serious consequences for human and animal health in addition to a significant economic impact on the livestock industry. Published and unpublished data on RVFV vector competence, vertebrate host competence, and mosquito feeding patterns from the United States were combined to quantitatively implicate mosquito vectors and vertebrate hosts that may be important to RVFV transmission in the United States. A viremia-vector competence relationship based on published mosquito transmission studies was used to calculate a vertebrate host competence index which was then combined with mosquito blood feeding patterns to approximate the vector and vertebrate amplification fraction, defined as the relative contribution of the mosquito or vertebrate host to pathogen transmission. Results implicate several Aedes spp. mosquitoes and vertebrates in the order Artiodactyla as important hosts for RVFV transmission in the U.S. Moreover, this study identifies critical gaps in knowledge which would be necessary to complete a comprehensive analysis identifying the different contributions of mosquitoes and vertebrates to potential RVFV transmission in the U.S. Future research should focus on (1) the dose-dependent relationship between viremic exposure and the subsequent infectiousness of key mosquito species, (2) evaluation of vertebrate host competence for RVFV among North American mammal species, with particular emphasis on the order Artiodactyla, and (3) identification of areas with a high risk for RVFV introduction so data on local vector and host populations can help generate geographically appropriate amplification fraction estimates. In anticipation of continued pathogen emergence in the U.S. due to globalization climate change, and other factors, the development of proactive management plans and interventions to predict and then intervene is going to be more efficient and effective than retrospective plans developed after pathogen emergence. Effective management of mosquito-borne pathogens like Rift Valley fever virus (RVFV) requires an understanding of the roles that different mosquito species and vertebrate hosts play in transmission. This study combines data on mosquito transmission efficiency, mosquito feeding patterns, and vertebrate infectiousness to quantitatively evaluate the relative importance of different mosquito species and vertebrate hosts to the amplification of RVFV in the U.S. We identify several species of floodwater Aedes spp. mosquitoes that would be the most likely vectors for RVFV, and hoofed ungulates (deer, cows, sheep) would be the most important amplifying vertebrate hosts. Although these data provide public and animal health agencies a priori knowledge on the primary mosquitoes that should be targeted for vector control and the highest priority animals to receive vaccines, this analysis reveals many gaps in knowledge reducing our ability to predict and then manage a potential invasion of RVFV.
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影响因子：
3.7
作者：
Hamer GL;Chaves LF;Anderson TK;Kitron UD;Brawn JD;Ruiz MO;Loss SR;Walker ED;Goldberg TL
通讯作者：
Goldberg TL
影响因子：
3.8
作者：
ANDERSON, GW;SLONE, TW;PETERS, CJ
通讯作者：
PETERS, CJ
影响因子：
5.8
作者：
Gora, D;Yaya, T;Gonzalez, JP
通讯作者：
Gonzalez, JP
影响因子：
5.5
作者：
ANDERSON, GW;LEE, JO;MEADORS, G
通讯作者：
MEADORS, G
DOI：
10.4269/ajtmh.1988.38.440
发表时间：
1988-03-01
影响因子：
3.3
作者：
GARGAN, TP;CLARK, GG;BAILEY, CL
通讯作者：
BAILEY, CL