Abnormal cortical growth in schizophrenia targets normative modules of synchronized development.
Abnormal cortical growth in schizophrenia targets normative modules of synchronized development.
复制标题
精神分裂症的异常皮质生长靶向同步发展的规范模块。
DOI：
10.1016/j.biopsych.2014.02.010
复制
发表时间：
2014-09-15
影响因子：
10.6
通讯作者：
Gogtay, Nitin
中科院分区：
文献类型：
--
作者：
Alexander-Bloch, Aaron F.;Reiss, Philip T.;Rapoport, Judith;McAdams, Harry;Giedd, Jay N.;Bullmore, Ed T.;Gogtay, Nitin
精神分裂症是一种大脑连接障碍和神经发育过程改变。不同年龄组的横断面病例对照研究表明，儿童期发作的精神分裂症患者的皮质厚度缺陷可能随着时间的推移而正常化，这表明皮质生长轨迹存在与疾病相关的差异。我们对106名儿童期精神分裂症患者和102名年龄匹配的健康志愿者进行了为期数年的MRI扫描。使用半参数回归，我们模拟了精神分裂症对8-30岁年龄范围内约80，000个皮质部位皮质厚度生长曲线的影响。此外，我们推导出规范的发展模块，组成的皮质区域具有相似的成熟轨迹的皮质厚度在典型的大脑发育。我们发现异常的非线性生长过程中，在前额叶和颞叶地区，以前曾被牵连在精神分裂症，区分第一次与年龄恒定的赤字在皮层厚度和区域之间的成熟轨迹被改变的精神分裂症。此外，我们发现，当大脑被分为五个规范的发展模块，与异常皮质生长的区域重叠显着只有扣带-额-颞模块。这些研究结果表明，精神分裂症的异常皮质发育可能是模块化的，或受到人类大脑连接体发育模块的正常社区结构的限制。
Schizophrenia is a disorder of brain connectivity and altered neurodevelopmental processes. Cross-sectional case-control studies in different age groups have suggested that deficits in cortical thickness in childhood-onset schizophrenia may normalize over time, suggesting a disorder-related difference in cortical growth trajectories. We acquired MRI scans repeated over several years for each subject, in a sample of 106 patients with childhood-onset schizophrenia and 102 age-matched healthy volunteers. Using semiparametric regression, we modeled the effect of schizophrenia on the growth curve of cortical thickness in ~80,000 locations across the cortex, in the age range 8–30. In addition, we derived normative developmental modules, composed of cortical regions with similar maturational trajectories for cortical thickness in typical brain development. We found abnormal non-linear growth processes in prefrontal and temporal areas that have previously been implicated in schizophrenia, distinguishing for the first time between cortical areas with age-constant deficits in cortical thickness and areas whose maturational trajectories are altered in schizophrenia. In addition, we showed that when the brain is divided into five normative developmental modules, the areas with abnormal cortical growth overlap significantly only with the cingulo-fronto-temporal module. These findings suggest that abnormal cortical development in schizophrenia may be modularized, or constrained by the normal community structure of developmental modules of the human brain connectome.
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DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM
影响因子：
34.7
作者：
Alexander-Bloch, Aaron;Giedd, Jay N.;Bullmore, Edward T.
通讯作者：
Bullmore, Edward T.
DOI：
10.1523/jneurosci.3554-12.2013
发表时间：
2013-02-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Alexander-Bloch A;Raznahan A;Bullmore E;Giedd J
通讯作者：
Giedd J
影响因子：
2.7
作者：
Benjamini, Yoav;Krieger, Abba M.;Yekutieli, Daniel
通讯作者：
Yekutieli, Daniel
影响因子：
--
作者：
Gogtay, Nitin;Greenstein, Deanna;Rapoport, Judith
通讯作者：
Rapoport, Judith