The Anyang Esophageal Cancer Cohort Study: study design, implementation of fieldwork, and use of computer-aided survey system.
The Anyang Esophageal Cancer Cohort Study: study design, implementation of fieldwork, and use of computer-aided survey system.
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安阳食管癌队列研究：研究设计、实地调查的实施以及计算机辅助调查系统的使用
DOI：
10.1371/journal.pone.0031602
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Ke Y
中科院分区：
文献类型：
--
作者：
Liu F;Guo F;Zhou Y;He Z;Tian X;Guo C;Ning T;Pan Y;Cai H;Ke Y
背景：人乳头瘤病毒(HPV)在食管鳞癌(ESCC)组织中反复出现。然而，HPV感染与食管鳞癌发病之间的因果关系仍不清楚。一项针对这一主题的大型队列研究正在中国安阳农村进行。方法/主要发现安阳食道癌队列研究(AECCS)是一项以人群为基础的前瞻性内窥镜队列研究，旨在调查HPV感染与食管鳞癌的关系。本白皮书提供了有关本研究的设计和实施的信息。我们特别描述了已经实施的招聘战略和质量控制程序，以及为这个项目使用的定制设计的计算机辅助调查系统(CASS)。该系统集成了条形码技术和唯一的识别码，并已开发为使用无线局域网促进整个工作流程的实时数据管理。共有8112名受试者(75.3%)参与了基线内窥镜检查；在两年后受邀参加第一轮随访的受试者中，91.9%的受试者遵守了这一要求。结论/意义AECCS研究在评估HPV感染与ESCC发生之间的因果关系方面具有很高的潜力。建立AECCS的经验可能有益于其他计划在发展中国家发起类似流行病学研究的国家。
Background Human papillomavirus (HPV) has been observed repeatedly in esophageal squamous cell carcinoma (ESCC) tissues. However, the causal relationship between HPV infection and the onset of ESCC remains unknown. A large cohort study focusing on this topic is being carried out in rural Anyang, China. Methodology/Principal Findings The Anyang Esophageal Cancer Cohort Study (AECCS) is a population-based prospective endoscopic cohort study designed to investigate the association of HPV infection and ESCC. This paper provides information regarding the design and implementation of this study. In particular we describe the recruitment strategies and quality control procedures which have been put into place, and the custom designed computer-aided survey system (CASS) used for this project. This system integrates barcode technology and unique identification numbers, and has been developed to facilitate real-time data management throughout the workflow using a wireless local area network. A total of 8,112 (75.3%) of invited subjects participated in the baseline endoscopic examination; of those invited two years later to take part in the first cycle of follow-up, 91.9% have complied. Conclusions/Significance The AECCS study has high potential for evaluating the causal relationship between HPV infection and the occurrence of ESCC. The experience in setting up the AECCS may be beneficial for others planning to initiate similar epidemiological studies in developing countries.
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影响因子：
254.7
作者：
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通讯作者：
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作者：
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通讯作者：
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