Determinants of microdamage in elderly human vertebral trabecular bone.
Determinants of microdamage in elderly human vertebral trabecular bone.
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DOI：
10.1371/journal.pone.0055232
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Chapurlat R
中科院分区：
文献类型：
--
作者：
Follet H;Farlay D;Bala Y;Viguet-Carrin S;Gineyts E;Burt-Pichat B;Wegrzyn J;Delmas P;Boivin G;Chapurlat R
以往的研究表明，由于生理负荷，微损伤会累积在骨中，并自然发生在人的松质骨中。本研究的目的是确定与人类椎体松质骨原有微损伤相关的因素，即年龄、结构、硬度、矿物和有机基质。骨小梁取自人L2椎体(n = 53)，取自54-95岁的供者(男22例，女30例，未知1例)，并对以前引用的参数进行了评估。测定周围松质骨胶原交联度(PYD、DPD、PEN和胶原百分含量)。我们发现，微损伤的决定因素主要是供体的年龄、建筑、矿物特性和成熟的酶交联物。此外，线性微裂纹主要与骨基质特性有关，而弥漫性损伤与结构有关。我们得出结论，线型和弥漫型微损伤似乎有不同的决定因素，年龄对这两种类型都是关键。
Previous studies have shown that microdamage accumulates in bone as a result of physiological loading and occurs naturally in human trabecular bone. The purpose of this study was to determine the factors associated with pre-existing microdamage in human vertebral trabecular bone, namely age, architecture, hardness, mineral and organic matrix. Trabecular bone cores were collected from human L2 vertebrae (n = 53) from donors 54–95 years of age (22 men and 30 women, 1 unknown) and previous cited parameters were evaluated. Collagen cross-link content (PYD, DPD, PEN and % of collagen) was measured on surrounding trabecular bone. We found that determinants of microdamage were mostly the age of donors, architecture, mineral characteristics and mature enzymatic cross-links. Moreover, linear microcracks were mostly associated with the bone matrix characteristics whereas diffuse damage was associated with architecture. We conclude that linear and diffuse types of microdamage seemed to have different determinants, with age being critical for both types.
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影响因子：
3.7
作者：
Karim L;Vashishth D
通讯作者：
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影响因子：
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作者：
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影响因子：
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DOI：
10.1615/critrevbiomedeng.v34.i3.20
发表时间：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1016/j.jmbbm.2011.05.017
发表时间：
2011-10-01
影响因子：
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作者：
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