Evaluation of Acromegaly patients with sleep disturbance related symptoms.
Evaluation of Acromegaly patients with sleep disturbance related symptoms.
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DOI：
10.12669/pjms.37.4.4229
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发表时间：
2021-07
影响因子：
2.2
通讯作者：
Ciftci B
中科院分区：
文献类型：
--
作者：
Celik D;Duyar SS;Aksu F;Firat S;Ciftci B
已知阻塞性睡眠呼吸暂停(OSA)的患病率在肢端肥大症中增加。这些患者由于软组织增多而导致的头面部畸形、巨舌症和喉壁增厚导致阻塞性睡眠呼吸暂停。此外，生长激素的增加会导致呼吸动力减弱，从而引发中枢性呼吸暂停。确定肢端肥大症患者的多导睡眠图特征对于揭示这些机制的影响很重要。对2011年至2018年在本院睡眠实验室接受多导睡眠图(PSG)检查的33例疑似睡眠障碍的肢端肥大症患者的人口学和多导睡眠图特征进行回顾性分析。其中一名患者被排除在分析之外，因为在术后期间进行了PSG。其余32例活动期肢端肥大症患者根据性别和OSA的存在进行分组，并在多导睡眠图和临床特征方面与统计方法进行比较。在32名活动期肢端肥大症患者(18名女性，14名男性)中，78.1%的患者因怀疑睡眠呼吸障碍而行PSG检查，发现OSA(AHI>；5)。中重度OSA占62.5%，男女之间OSA的发现率和严重程度无明显差异。呼吸系统事件似乎主要是阻塞性低呼吸。此外，女性和男性OSA肢端肥大症患者的多导睡眠图特征也是相似的。可以看出，OSA组在身体质量指数(BMI)方面与单纯鼾症组相似，但在统计学上明显年龄更大(p=0.007)。经两两相关分析，年龄与AHI呈正相关(r：0.426，p：0.015)。考虑到OSA在人群中的患病率约为5%，我们的结果显示OSA在肢端肥大症中的风险增加，而阻塞性途径在这种增加中是有效的。OSA的发生概率和多导睡眠图特征在性别之间是相似的。虽然OSA组和无OSA组的BMI中位数相近，但OSA组的中位年龄较高，即使没有明显的肥胖，中年肢端肥大症患者也应该根据OSA进行评估。
It is known that the prevalence of obstructive sleep apnea (OSA) is increased in acromegaly. Craniofacial anomalies, macroglossia, and thickening of the laryngeal wall caused by the increase in soft tissue in these patients lead to OSA. Also, the increase in growth hormone can trigger central apnea by causing a decrease in respiratory drive. Determining the polysomnographic characteristics of acromegaly patients is important to reveal the effect of these mechanisms. The demographic and polysomnographic characteristics of 33 acromegaly patients who underwent polysomnography (PSG) with suspicion of sleep disorders between 2011 and 2018 in the sleep laboratory of our hospital were retrospectively analyzed. One of the patients was excluded from the analysis because PSG was performed in the postoperative period. The remaining 32 patients with active acromegaly were grouped according to their gender and the presence of OSA and compared with statistical methods in terms of polysomnographic and clinical features. OSA (AHI>5) was detected in 78.1% of 32 active acromegaly patients (18 females, 14 males) who underwent PSG with suspicion of sleep-disordered breathing. Moderate-severe OSA (62.5%) was found in most patients, and there was no difference between the sexes in terms of OSA detection rate and OSA severity. Respiratory events appear to be predominantly obstructive hypopneas. Also, the polysomnographic features of female and male acromegaly patients with OSA were found to be similar. It is seen that the OSA group is similar to the group with simple snoring in terms of body mass index (BMI), but is statistically significantly older (p=0,007). A positive correlation was found between age and AHI in pairwise correlation analysis (r:0,426 p:0,015, respectively). Considering that the prevalence of OSA in the population is approximately 5%, our results show that the risk of OSA in acromegaly increases, and obstructive pathways are effective in this increase. The probability of OSA occurrence and polysomnographic features between the genders are similar. Although the median BMI of the patients with and without OSA was similar, the median age was higher in the group with OSA, middle-aged acromegaly patients should be evaluated in terms of OSA even if there is no obvious obesity.
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DOI：
10.2174/1874306401206010028
发表时间：
2012
期刊：
The open respiratory medicine journal
影响因子：
--
作者：
Hernández-Gordillo D;Ortega-Gómez Mdel R;Galicia-Polo L;Castorena-Maldonado A;Vergara-López A;Guillén-González MÁ;Torre-Bouscoulet L
通讯作者：
Torre-Bouscoulet L
影响因子：
0.9
作者：
Pazarli, Ahmet Cemal;Koseoglu, Handan Inonu;Gokce, Erkan
通讯作者：
Gokce, Erkan
影响因子：
2.3
作者：
Tasbakan, Mehmet Sezai;Kacmaz Basoglu, Ozen;Saygili, Fusun
通讯作者：
Saygili, Fusun
影响因子：
24.3
作者：
Hochban, W;Ehlenz, K;Brandenburg, U
通讯作者：
Brandenburg, U
影响因子：
5.4
作者：
Celik, O.;Kadioglu, P.
通讯作者：
Kadioglu, P.