Remote Memory in Epilepsy: Assessment, Impairment, and Implications Regarding Hippocampal Function.
Remote Memory in Epilepsy: Assessment, Impairment, and Implications Regarding Hippocampal Function.
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DOI：
10.3389/fneur.2022.855332
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发表时间：
2022
影响因子：
3.4
通讯作者：
Leeman-Markowski, Beth A.
中科院分区：
文献类型：
--
作者：
Rastogi, Sanya;Meador, Kimford J.;Barr, William B.;Devinsky, Orrin;Leeman-Markowski, Beth A.
关键词：
对癫痫患者的研究提供了对人类记忆神经科学的深入了解。患有远程记忆缺陷的患者可能会学到新信息，但很难回忆起过去几年的事件。远距离记忆损伤的过程尚不清楚，可能是多种因素相互作用的结果，包括海马功能障碍。随着时间的推移，海马体可能在远程语义和情景记忆存储中发挥持续的作用，而内侧颞叶癫痫（TLE）患者尤其面临缺陷的风险。研究重点是远程记忆的偏侧化，通常对左侧 TLE 造成更大的损害，这可能与言语任务需求有关。远程内存测试受到方法限制的限制。因此，赤字难以衡量。这篇对远程记忆的综述重点关注其基础神经生物学的证据、对海马功能的理论意义以及使癫痫患者测试复杂化的方法学困难。
Studies of epilepsy patients provide insight into the neuroscience of human memory. Patients with remote memory deficits may learn new information but have difficulty recalling events from years past. The processes underlying remote memory impairment are unclear and likely result from the interaction of multiple factors, including hippocampal dysfunction. The hippocampus likely has a continued role in remote semantic and episodic memory storage over time, and patients with mesial temporal lobe epilepsy (TLE) are at particular risk for deficits. Studies have focused on lateralization of remote memory, often with greater impairment in left TLE, which may relate to verbal task demands. Remote memory testing is restricted by methodological limitations. As a result, deficits have been difficult to measure. This review of remote memory focuses on evidence for its underlying neurobiology, theoretical implications for hippocampal function, and methodological difficulties that complicate testing in epilepsy patients.
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影响因子：
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