Associations between Inflammatory Markers and Subclinical Atherosclerosis in Middle-aged White, Japanese-American and Japanese Men: The ERA-JUMP Study.
Associations between Inflammatory Markers and Subclinical Atherosclerosis in Middle-aged White, Japanese-American and Japanese Men: The ERA-JUMP Study.
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DOI：
10.5551/jat.23580
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发表时间：
2015
影响因子：
4.4
通讯作者：
ERA-JUNP Study Group
中科院分区：
文献类型：
--
作者：
Nagasawa SY;Ohkubo T;Masaki K;Barinas-Mitchell E;Miura K;Seto T;El-Saed A;Kadowaki T;Willcox BJ;Edmundowicz D;Kadota A;Evans RW;Kadowaki S;Fujiyoshi A;Hisamatsu T;Bertolet MH;Okamura T;Nakamura Y;Kuller LH;Ueshima H;Sekikawa A;ERA-JUNP Study Group
研究炎症标志物C-反应蛋白(CRP)和纤维蛋白原是否与包括亚洲人在内的普通男性人群中动脉粥样硬化的生物标志物[颈动脉内中膜厚度(IMT)和冠状动脉钙化(CAC)]相关。以人群为基础的310名日本人、293名日裔美国人和297名白人男性，年龄40-49岁，没有临床心血管疾病，采用标准化方法测量IMT、CAC、CRP和纤维蛋白原水平以及其他常规危险因素。使用多元线性或Logistic回归模型评估变量之间的统计关联。日本人组的炎症标志物水平和亚临床动脉粥样硬化水平显著低于日裔美国人组和白人组(P值均为0.001)。C反应蛋白和纤维蛋白原水平分别为255.0和313.0 mg/dl和291.5 mg/dl。颈动脉平均IMT分别为0.61 mm、0.73 mm和0.68 mm，CAC患病率分别为11.6%、32.1%和26.3%。体重指数(BMI)与C反应蛋白和纤维蛋白原水平呈显著正相关。尽管在日本男性中，CRP与IMT显著正相关，但在调整了传统危险因素或BMI后，这种相关性变得不显著。在所有三个人群中，C反应蛋白与CAC的患病率均无显著相关性。同样，纤维蛋白原与IMT或CAC的患病率均无显著相关性。炎性标记物与亚临床动脉粥样硬化的相关性可能仅反映了东方和西方人群中BMI与炎性标记物和亚临床动脉粥样硬化的强烈关联。
To examine whether the inflammatory markers, C-reactive protein (CRP) and fibrinogen, are associated with biomarkers of atherosclerosis [carotid intima-media thickness (IMT) and coronary artery calcification (CAC)] in the general male population, including Asians. Population-based samples of 310 Japanese, 293 Japanese-American and 297 White men aged 40-49 years without clinical cardiovascular disease had IMT, CAC, CRP and fibrinogen levels, and other conventional risk factors measured using standardized methods. Statistical associations between the variables were evaluated using multiple linear or logistic regression models. The Japanese group had significantly lower levels of inflammatory markers and subclinical atherosclerosis than the Japanese-American and White groups (P-values all <0.001). The mean levels of CRP were 0.66 vs. 1.11 and 1.47 mg/L, and fibrinogen 255.0 vs. 313.0 and 291.5 mg/dl, respectively. Mean carotid IMT was 0.61 vs. 0.73 and 0.68 mm, and the prevalence of CAC 11.6% vs. 32.1% and 26.3%, respectively. Body mass index (BMI) showed significant positive associations with both CRP and fibrinogen levels. Although CRP showed a significant positive association with IMT in Japanese men, this association became non-significant after adjustment for traditional risk factors or BMI. In all three populations, CRP was not associated significantly with the prevalence of CAC. Similarly, fibrinogen did not show a significant association with either IMT or the prevalence of CAC. The associations of inflammatory markers with subclinical atherosclerosis may merely reflect the strong association of BMI with inflammatory markers and subclinical atherosclerosis in both Eastern and Western populations.
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DOI：
10.1016/0021-9681(74)90014-9
发表时间：
1974-01-01
期刊：
JOURNAL OF CHRONIC DISEASES
影响因子：
--
作者：
KAGAN, A;HARRIS, BR;TILLOTSON, J
通讯作者：
TILLOTSON, J
影响因子：
15.1
作者：
Coe, Christopher L.;Love, Gayle D.;Ryff, Carol D.
通讯作者：
Ryff, Carol D.
DOI：
10.1161/01.atv.0000225701.20965.b9
发表时间：
2006-07-01
影响因子：
8.7
作者：
Miura, Katsuyuki;Nakagawa, Hideaki;Stamler, Jeremiah
通讯作者：
Stamler, Jeremiah
动脉粥样硬化的炎症。
DOI：
10.1161/atvbaha.108.179705
发表时间：
2012-09
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Libby P
通讯作者：
Libby P
DOI：
10.1016/0735-1097(90)90282-t
发表时间：
1990-03-15
影响因子：
24
作者：
AGATSTON, AS;JANOWITZ, WR;DETRANO, R
通讯作者：
DETRANO, R