Current understanding of thalamic structure and function in migraine.

Current understanding of thalamic structure and function in migraine.
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DOI:
10.1177/0333102418791595
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发表时间:
2019-11
期刊:
Cephalalgia : an international journal of headache
影响因子:
--
通讯作者:
Ashina M
Ashina M
中科院分区:
其他
文献类型:
--
作者:
Younis S;Hougaard A;Noseda R;Ashina M

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回顾和讨论有关丘脑结构和功能在偏头痛中的作用的文献。丘脑在我们对偏头痛的异常性疼痛、中枢敏化和畏光的理解中占有重要地位。结构和功能研究结果表明丘脑和各个皮质区域之间的功能连接异常,表明偏头痛的疼痛处理发生了改变。药理学伤害感受调节表明丘脑是潜在的药物靶点。丘脑在偏头痛相关的异常性疼痛和畏光中的关键作用已得到充分证实。此外,丘脑很可能参与偏头痛的功能失调的疼痛调节和处理,但需要进一步的研究来阐明这些发现的确切临床意义。
To review and discuss the literature on the role of thalamic structure and function in migraine. The thalamus holds an important position in our understanding of allodynia, central sensitization and photophobia in migraine. Structural and functional findings suggest abnormal functional connectivity between the thalamus and various cortical regions pointing towards an altered pain processing in migraine. Pharmacological nociceptive modulation suggests that the thalamus is a potential drug target. A critical role for the thalamus in migraine-related allodynia and photophobia is well established. Additionally, the thalamus is most likely involved in the dysfunctional pain modulation and processing in migraine, but further research is needed to clarify the exact clinical implications of these findings.
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发表时间: 2016-01-01
影响因子: 5.1
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