The Regulation of Inflammation by Innate and Adaptive Lymphocytes.
The Regulation of Inflammation by Innate and Adaptive Lymphocytes.
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DOI：
10.1155/2018/1467538
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发表时间：
2018
影响因子：
4.1
通讯作者：
Strutt TM
中科院分区：
文献类型：
--
作者：
Cronkite DA;Strutt TM
炎症在控制病原体和形成随后的适应性免疫应答中起着至关重要的作用。传统上，先天免疫被描述为通过一般和非特异性手段触发的快速反应，根据定义缺乏记忆能力。最近，已经清楚的是，一些先天免疫细胞是表观遗传学重新编程或“印记”过去的经验。这些“训练过的”先天免疫细胞在随后遇到病原体时显示出改变的炎症反应。对过去病原体遭遇的记忆通常归因于感染消退后抗原特异性记忆T和B细胞群。在回忆反应期间，记忆T和B细胞通过增殖、产生效应细胞因子和执行各种效应功能来快速响应。记忆性CD4和CD8 T细胞的一个经常被忽视的效应子功能是在感染的初始部位促进炎症环境，这反映了初次接触。这种记忆调节的炎症反应与其他次级效应T细胞功能结合，导致感染和相关组织病理学的更好控制和更快解决。最近的进展，我们的理解炎症触发器，印迹的先天免疫反应，和调节炎症的T细胞记忆的作用进行了讨论。
Inflammation plays an essential role in the control of pathogens and in shaping the ensuing adaptive immune responses. Traditionally, innate immunity has been described as a rapid response triggered through generic and nonspecific means that by definition lacks the ability to remember. Recently, it has become clear that some innate immune cells are epigenetically reprogrammed or “imprinted” by past experiences. These “trained” innate immune cells display altered inflammatory responses upon subsequent pathogen encounter. Remembrance of past pathogen encounters has classically been attributed to cohorts of antigen-specific memory T and B cells following the resolution of infection. During recall responses, memory T and B cells quickly respond by proliferating, producing effector cytokines, and performing various effector functions. An often-overlooked effector function of memory CD4 and CD8 T cells is the promotion of an inflammatory milieu at the initial site of infection that mirrors the primary encounter. This memory-conditioned inflammatory response, in conjunction with other secondary effector T cell functions, results in better control and more rapid resolution of both infection and the associated tissue pathology. Recent advancements in our understanding of inflammatory triggers, imprinting of the innate immune responses, and the role of T cell memory in regulating inflammation are discussed.
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影响因子：
3.6
作者：
Castellano, G;Woltman, AM;van Kooten, C
通讯作者：
van Kooten, C
DOI：
10.1126/science.1179050
发表时间：
2009-10-09
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Amit I;Garber M;Chevrier N;Leite AP;Donner Y;Eisenhaure T;Guttman M;Grenier JK;Li W;Zuk O;Schubert LA;Birditt B;Shay T;Goren A;Zhang X;Smith Z;Deering R;McDonald RC;Cabili M;Bernstein BE;Rinn JL;Meissner A;Root DE;Hacohen N;Regev A
通讯作者：
Regev A
影响因子：
5.4
作者：
Arlehamn, Cecilia S. Lindestam;Lewinsohn, David;Lewinsohn, Deborah
通讯作者：
Lewinsohn, Deborah
影响因子：
--
作者：
Bekkering, Siroon;Blok, Bastiaan A.;Netea, Mihai G.
通讯作者：
Netea, Mihai G.
影响因子：
64.5
作者：
Cadwell K;Patel KK;Maloney NS;Liu TC;Ng AC;Storer CE;Head RD;Xavier R;Stappenbeck TS;Virgin HW
通讯作者：
Virgin HW