Effect of dietary copper addition on lipid metabolism in rabbits.
Effect of dietary copper addition on lipid metabolism in rabbits.
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DOI：
10.1080/16546628.2017.1348866
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发表时间：
2017
影响因子：
3.3
通讯作者：
Fuchang L
中科院分区：
文献类型：
--
作者：
Lei L;Xiaoyi S;Fuchang L
本研究旨在探讨补铜对家兔脂代谢的影响。结果表明，与对照组相比，日粮中添加铜（5-45 mg/kg）可显著提高体质量，但降低脂肪和肝脏重量（P < 0.05）。添加铜（45 mg/kg）显著增加骨骼肌重量，但抑制肝脏、骨骼肌和脂肪组织中细胞质脂质的积累（P < 0.05）。与对照组相比，日粮中添加铜（45 mg/kg）显著提高血浆甘油三酯水平，降低极低密度脂蛋白水平（P < 0.05）。铜处理显著增加肝脏中肉毒碱棕榈酰转移酶（CPT）1、CPT 2和过氧化物酶体增殖物激活受体（PPAR）a的基因表达（P < 0.05）。在骨骼肌中，CPT 1、CPT 2、脂肪酸转运蛋白、脂肪酸结合蛋白、PPARa mRNA以及磷酸化AMP活化蛋白激酶（AMPK）水平均显著上调（P < 0.05）。补铜组脂肪组织中CPT 1、CPT 2、PPARa和脂肪酶敏感性脂肪酶mRNA水平显著高于对照组（P < 0.05）。总之，铜促进骨骼肌生长并减少脂肪堆积。肝脏、骨骼肌和脂肪组织中的PPARa信号和骨骼肌组织中的AMPK信号参与铜对脂质代谢的调节。
The present study was conducted to investigate the effect of copper supplementation on lipid metabolism in rabbits. Our study showed dietary copper addition (5-45 mg/kg) increased body mass gain, but decreased fat and liver weights compared with those in the control group (P < 0.05). Copper (45 mg/kg) addition significantly increased the skeletal muscle weight, but inhibited cytoplasmic lipid accumulation in liver, skeletal muscle and adipose tissue (P < 0.05). Compared with the control group, dietary copper addition (45 mg/kg) significantly increased plasma triglyceride levels but decreased very low density lipoprotein levels (P < 0.05). Copper treatment significantly increased gene expression of carnitine palmitoyltransferase (CPT) 1, CPT2 and peroxisome proliferator-activated receptor (PPAR) a in liver (P < 0.05). In skeletal muscle, CPT1, CPT2, fatty acid transport protein, fatty acid-binding protein, and PPARa mRNA as well as phosphorylated AMP-activated protein kinase (AMPK) levels were significantly up-regulated by copper treatment (P < 0.05). Rabbits receiving copper supplementation had higher CPT1, CPT2, PPARa and hormone-sensitive lipase mRNA levels in adipose tissue (P < 0.05). In conclusion, copper promoted skeletal muscle growth and reduced fat accretion. PPARa signaling in liver, skeletal muscle and adipose tissues and AMPK signaling in skeletal muscle tissue were involved in the regulation of lipid metabolism by copper.
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影响因子：
4.4
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影响因子：
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