A systematic review of the histological and molecular changes in rotator cuff disease.
A systematic review of the histological and molecular changes in rotator cuff disease.
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DOI：
10.1302/2046-3758.17.2000115
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发表时间：
2012-07
影响因子：
4.6
通讯作者：
Carr AJ
中科院分区：
文献类型：
--
作者：
Dean BJ;Franklin SL;Carr AJ
肩袖疾病（RCD）的发病机制很复杂且尚未完全了解。本系统综述旨在总结整个 RCD 谱系中发生的组织学和分子变化。我们对科学文献进行了系统回顾，并制定了具体的纳入和排除标准。共有 101 项研究符合纳入标准：92 项研究仅使用人类受试者，7 项研究使用动物过度使用模型，其余两项研究同时涉及人类和动物过度使用模型。共有 58 项研究专门分析了冈上肌腱，16 项研究专门分析了肩峰下的滑囊组织，而其他研究则分析了其他组织或不同的组织类型组合，包括关节液和肌肉。 RCD 中改变的分子生物标志物包括基质物质、生长因子、酶和其他蛋白质，包括某些神经肽。由于分子医学的最新重大进展，RCD 的发病机制正在慢慢被阐明。旨在进一步解开这些关键分子过程的未来研究对于开发新的 RCD 诊断和治疗外科干预措施至关重要。
The pathogenesis of rotator cuff disease (RCD) is complex and not fully understood. This systematic review set out to summarise the histological and molecular changes that occur throughout the spectrum of RCD. We conducted a systematic review of the scientific literature with specific inclusion and exclusion criteria. A total of 101 studies met the inclusion criteria: 92 studies used human subjects exclusively, seven used animal overuse models, and the remaining two studies involved both humans and an animal overuse model. A total of 58 studies analysed supraspinatus tendon exclusively, 16 analysed subacromial bursal tissue exclusively, while the other studies analysed other tissue or varying combinations of tissue types including joint fluid and muscle. The molecular biomarkers that were altered in RCD included matrix substances, growth factors, enzymes and other proteins including certain neuropeptides. The pathogenesis of RCD is being slowly unravelled as a result of the significant recent advances in molecular medicine. Future research aimed at further unlocking these key molecular processes will be pivotal in developing new surgical interventions both in terms of the diagnosis and treatment of RCD.
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影响因子：
2.8
作者：
Attia, Mohamed;Scott, Alexander;Martelly, Isabelle
通讯作者：
Martelly, Isabelle
影响因子：
3
作者：
Feeney, MS;O'Dowd, J;Colville, J
通讯作者：
Colville, J
影响因子：
82.9
作者：
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通讯作者：
Young, Marian F.
影响因子：
2.8
作者：
Blaine, Theodore A.;Cote, Mindy A.;Bigliani, Louis U.
通讯作者：
Bigliani, Louis U.
影响因子：
2.8
作者：
Chang, Hsiang-Ning;Pang, Jong-Hwei S.;Yang, Yun-Ming
通讯作者：
Yang, Yun-Ming