Role of sex steroid hormones in bacterial-host interactions.
Role of sex steroid hormones in bacterial-host interactions.
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DOI：
10.1155/2013/928290
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发表时间：
2013
影响因子：
--
通讯作者：
Camacho-Arroyo I
中科院分区：
文献类型：
--
作者：
García-Gómez E;González-Pedrajo B;Camacho-Arroyo I
性类固醇激素在生殖和非生殖组织（包括免疫细胞）中发挥着重要的生理作用。这些激素通过结合作为配体依赖性转录因子的特定细胞内受体或刺激多种信号转导途径的膜受体来发挥其功能。男性对细菌感染的易感性升高可能与男性的免疫反应通常比女性低有关。这种二态性差异主要是由于性类固醇激素通过控制促炎和抗炎细胞因子表达以及toll样受体（TLRs）表达和抗体产生来调节免疫系统的差异。此外，性激素还会影响致病菌的代谢、生长或毒力。反过来，病原菌群、微生物群和环境细菌能够代谢和降解类固醇激素及其相关化合物。所有这些数据表明，性类固醇激素在调节细菌-宿主相互作用中起着关键作用。
Sex steroid hormones play important physiological roles in reproductive and nonreproductive tissues, including immune cells. These hormones exert their functions by binding to either specific intracellular receptors that act as ligand-dependent transcription factors or membrane receptors that stimulate several signal transduction pathways. The elevated susceptibility of males to bacterial infections can be related to the usually lower immune responses presented in males as compared to females. This dimorphic sex difference is mainly due to the differential modulation of the immune system by sex steroid hormones through the control of proinflammatory and anti-inflammatory cytokines expression, as well as Toll-like receptors (TLRs) expression and antibody production. Besides, sex hormones can also affect the metabolism, growth, or virulence of pathogenic bacteria. In turn, pathogenic, microbiota, and environmental bacteria are able to metabolize and degrade steroid hormones and their related compounds. All these data suggest that sex steroid hormones play a key role in the modulation of bacterial-host interactions.
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DOI：
10.1038/nri2394
发表时间：
2008-09
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Fish EN
通讯作者：
Fish EN
影响因子：
2.7
作者：
Clark, DT;Soory, M
通讯作者：
Soory, M
影响因子：
2.7
作者：
Benten, WPM;Guo, Z;Wunderlich, F
通讯作者：
Wunderlich, F
影响因子：
2.1
作者：
Hosoda, Kouichi;Shimomura, Hirofumi;Hirai, Yoshikazu
通讯作者：
Hirai, Yoshikazu
影响因子：
7.1
作者：
BOKKENHEUSER, VD;WINTER, J
通讯作者：
WINTER, J