Aorta Regulatory T Cells with a Tissue-Specific Phenotype and Function Promote Tissue Repair through Tff1 in Abdominal Aortic Aneurysms.
Aorta Regulatory T Cells with a Tissue-Specific Phenotype and Function Promote Tissue Repair through Tff1 in Abdominal Aortic Aneurysms.
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DOI：
10.1002/advs.202104338
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Cheng X
中科院分区：
文献类型：
--
作者：
Li J;Xia N;Li D;Wen S;Qian S;Lu Y;Gu M;Tang T;Jiao J;Lv B;Nie S;Hu D;Liao Y;Yang X;Shi G;Cheng X
除了维持免疫耐受外，Foxp 3+调节性T细胞（Tcells）在组织稳态和重塑中执行专门的功能。然而，主动脉瘤中的TdR是否具有组织特异性表型和功能尚不清楚。在这里，一个特殊的组TAPs，可能抑制腹主动脉瘤（AAA）的进展进行了鉴定和功能的特点。主动脉瘤在AAA过程中逐渐增加，主要从外周循环募集。单细胞TCR测序和批量RNA测序证明了它们独特的表型和高表达的三叶因子1（Tff 1）。Foxp 3cre/creTff 1flox/flox小鼠用于阐明Tff 1在AAA中的作用，表明主动脉平滑肌细胞（SMC）分泌Tff 1以调节平滑肌细胞（SMC）存活。体外实验证实Tff 1通过细胞外信号调节激酶（ERK）1/2途径抑制SMC凋亡。这些发现揭示了主动脉瘤的组织特异性表型和功能，并可能为预防AAA提供一种有前途的新方法。一组具有组织特异性表型和功能的Tff 1可能通过Tff 1保护腹主动脉瘤进展。
In addition to maintaining immune tolerance, Foxp3+ regulatory T cells (Tregs) perform specialized functions in tissue homeostasis and remodeling. However, whether Tregs in aortic aneurysms have a tissue‐specific phenotype and function is unclear. Here, a special group of Tregs that potentially inhibit abdominal aortic aneurysm (AAA) progression are identified and functionally characterized. Aortic Tregs gradually increase during the process of AAA and are mainly recruited from peripheral circulation. Single‐cell TCR sequencing and bulk RNA sequencing demonstrate their unique phenotype and highly expressed trefoil factor 1 (Tff1). Foxp3cre/creTff1flox/flox mice are used to clarify the role of Tff1 in AAA, suggesting that aortic Tregs secrete Tff1 to regulate smooth muscle cell (SMC) survival. In vitro experiments confirm that Tff1 inhibits SMC apoptosis through the extracellular signal‐regulated kinase (ERK) 1/2 pathway. The findings reveal a tissue‐specific phenotype and function of aortic Tregs and may provide a promising and novel approach for the prevention of AAA. A group of Tregs with a tissue‐specific phenotype and function potentially protects abdominal aortic aneurysm progression via Tff1.
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DOI：
10.1161/atvbaha.118.312023
发表时间：
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影响因子：
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期刊：
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影响因子：
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